Molecular characterization of invasive Streptococcus dysgalactiae subsp. Equisimilis, Japan

Takeaki Wajima, Miyuki Morozumi, Shigeo Hanada, Katsuhiko Sunaoshi, Naoko Chiba, Satoshi Iwata, Kimiko Ubukata

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Abstract

We collected β-hemolytic streptococci (1,611 isolates) from patients with invasive streptococcal infections in Japan during April 2010–March 2013. Streptococcus dysgalactiae subsp. equisimilis (SDSE) was most common (n = 693); 99%m of patients with SDSE infections were elderly (mean age 75 years, SD ±15 years). We aimed to clarify molecular and epidemiologic characteristics of SDSE isolates and features of patient infections. Bacteremia with no identified focus of origin and cellulitis were the most prevalent manifestations; otherwise, clinical manifestations resembled those of S. pyogenes infections. Clinical manifestations also differed by patient’s age. SDSE isolates were classified into 34 emm types; stG6792 was most prevalent (27.1%), followed by stG485 and stG245. Mortality rates did not differ according to emm types. Multilocus sequence typing identified 46 sequence types and 12 novel types. Types possessing macrolide-and quinolone-resistance genes were 18.4% and 2.6%, respectively; none showed blactam resistance. Among aging populations, invasive SDSE infections are an increasing risk.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalEmerging Infectious Diseases
Volume22
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Wajima, T., Morozumi, M., Hanada, S., Sunaoshi, K., Chiba, N., Iwata, S., & Ubukata, K. (2016). Molecular characterization of invasive Streptococcus dysgalactiae subsp. Equisimilis, Japan. Emerging Infectious Diseases, 22(2), 247-254. https://doi.org/10.3201/eid2202.141732