Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin Aα)

Taro Muramatsu, Randall L. Kincaid

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A complementary DNA for human calcineurin Aα (protein phosphatase-2B), encoding a protein of 521 amino acids, was isolated from a hippocampus library. The deduced human sequence differs from that of mouse in only two amino acids, demonstrating that the structure of this catalytic subunit has been strictly conserved during mammalian evolution. Such high homology is in contrast to that seen for calcineurin Aγ, an isoform that shows only 88% identity between human and mouse (Muramatsu, T. and Kincaid, R.L. (1992) Biochem. Biophys. Res. Commun. 188, 265-271).

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalBBA - Molecular Cell Research
Volume1178
Issue number1
DOIs
Publication statusPublished - 1993 Jul 28
Externally publishedYes

Keywords

  • (Human)
  • Amino acid sequence
  • Calcineurin
  • cDNA sequence

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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