TY - JOUR
T1 - Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin Aα)
AU - Muramatsu, Taro
AU - Kincaid, Randall L.
PY - 1993/7/28
Y1 - 1993/7/28
N2 - A complementary DNA for human calcineurin Aα (protein phosphatase-2B), encoding a protein of 521 amino acids, was isolated from a hippocampus library. The deduced human sequence differs from that of mouse in only two amino acids, demonstrating that the structure of this catalytic subunit has been strictly conserved during mammalian evolution. Such high homology is in contrast to that seen for calcineurin Aγ, an isoform that shows only 88% identity between human and mouse (Muramatsu, T. and Kincaid, R.L. (1992) Biochem. Biophys. Res. Commun. 188, 265-271).
AB - A complementary DNA for human calcineurin Aα (protein phosphatase-2B), encoding a protein of 521 amino acids, was isolated from a hippocampus library. The deduced human sequence differs from that of mouse in only two amino acids, demonstrating that the structure of this catalytic subunit has been strictly conserved during mammalian evolution. Such high homology is in contrast to that seen for calcineurin Aγ, an isoform that shows only 88% identity between human and mouse (Muramatsu, T. and Kincaid, R.L. (1992) Biochem. Biophys. Res. Commun. 188, 265-271).
KW - (Human)
KW - Amino acid sequence
KW - Calcineurin
KW - cDNA sequence
UR - http://www.scopus.com/inward/record.url?scp=0027321124&partnerID=8YFLogxK
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U2 - 10.1016/0167-4889(93)90117-8
DO - 10.1016/0167-4889(93)90117-8
M3 - Article
C2 - 8392375
AN - SCOPUS:0027321124
SN - 0167-4889
VL - 1178
SP - 117
EP - 120
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 1
ER -