Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Kazunobu Toshima, Ryusuke Takano, Tomohiro Ozawa, Shuichi Matsumura

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.

Original languageEnglish
Pages (from-to)212-213
Number of pages2
JournalChemical Communications
Volume2
Issue number3
DOIs
Publication statusPublished - 2002 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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