Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Kazunobu Toshima, Ryusuke Takano, Tomohiro Ozawa, Shuichi Matsumura

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.

Original languageEnglish
Pages (from-to)212-213
Number of pages2
JournalChemical Communications
Issue number3
Publication statusPublished - 2002 Feb 7

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Quinoxalines
Carbohydrates
DNA
Antibiotics
Hybrid systems
Ultraviolet radiation
Guanine
Irradiation
Wavelength
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents. / Toshima, Kazunobu; Takano, Ryusuke; Ozawa, Tomohiro; Matsumura, Shuichi.

In: Chemical Communications, No. 3, 07.02.2002, p. 212-213.

Research output: Contribution to journalArticle

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