Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Kazunobu Toshima; Masashi Hasegawa; Junji Shimizu; Shuichi Matsumura

Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Kazunobu Toshima, Masashi Hasegawa, Junji Shimizu, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

Original language	English
Pages (from-to)	28-35
Number of pages	8
Journal	Arkivoc
Volume	2004
Issue number	13
Publication status	Published - 2004 Aug 23

Keywords

Anthracene
Carbohydrate
Cytotoxicity
DNA cleavage
Photoirradiation

ASJC Scopus subject areas

Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.",

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author = "Kazunobu Toshima and Masashi Hasegawa and Junji Shimizu and Shuichi Matsumura",

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T1 - Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

AU - Toshima, Kazunobu

AU - Hasegawa, Masashi

AU - Shimizu, Junji

AU - Matsumura, Shuichi

PY - 2004/8/23

Y1 - 2004/8/23

N2 - The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

AB - The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

KW - Anthracene

KW - Carbohydrate

KW - Cytotoxicity

KW - DNA cleavage

KW - Photoirradiation

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UR - http://www.scopus.com/inward/citedby.url?scp=5044239643&partnerID=8YFLogxK

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AN - SCOPUS:5044239643

SN - 1424-6376

VL - 2004

SP - 28

EP - 35

JO - Arkivoc

JF - Arkivoc

IS - 13

ER -

Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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