Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Kazunobu Toshima, Masashi Hasegawa, Junji Shimizu, Shuichi Matsumura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalArkivoc
Volume2004
Issue number13
Publication statusPublished - 2004 Aug 23

Fingerprint

Cytotoxins
Carbohydrates
DNA
Guanine
Cytotoxicity
Hybrid systems
Ultraviolet radiation
Cells
Irradiation
Wavelength
anthracene

Keywords

  • Anthracene
  • Carbohydrate
  • Cytotoxicity
  • DNA cleavage
  • Photoirradiation

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents. / Toshima, Kazunobu; Hasegawa, Masashi; Shimizu, Junji; Matsumura, Shuichi.

In: Arkivoc, Vol. 2004, No. 13, 23.08.2004, p. 28-35.

Research output: Contribution to journalArticle

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