Molecular design, chemical synthesis, and evaluation of cytosine-carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA

Yusuke Idutsu, Ayaka Sasaki, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The designed cytosine-carbohydrate hybrid molecule selectively recognized and stabilized the bulged duplex DNA possessing the complementary bulged DNA base, guanine, while the nucleotide base itself did not exhibit any such ability. It was also found that the assistance of the carbohydrate to stabilize the interaction between the nucleotide base and the complementally bulge DNA base is very helpful for the selective recognition and stabilization of the single-bulged duplex DNA.

Original languageEnglish
Pages (from-to)4332-4335
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
Publication statusPublished - 2005 Oct 1

Keywords

  • Bulge
  • Carbohydrate
  • DNA
  • Molecular recognition
  • Nucleotide base

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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