Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers

Masashi Hasegawa, Akane Suzuki, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substituent into anthracene core skeleton.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalScience and Technology of Advanced Materials
Volume7
Issue number2
DOIs
Publication statusPublished - 2006 Mar 1

Keywords

  • Anthracene
  • Carbohydrate
  • Cleavage
  • Photoirradiation, Hybrid
  • Protein

ASJC Scopus subject areas

  • Materials Science(all)

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