Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers

Masashi Hasegawa; Akane Suzuki; Shuichi Matsumura; Kazunobu Toshima

doi:10.1016/j.stam.2005.11.024

Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers

Masashi Hasegawa, Akane Suzuki, Shuichi Matsumura, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substituent into anthracene core skeleton.

Original language	English
Pages (from-to)	169-174
Number of pages	6
Journal	Science and Technology of Advanced Materials
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.stam.2005.11.024
Publication status	Published - 2006 Mar

Keywords

Anthracene
Carbohydrate
Cleavage
Photoirradiation, Hybrid
Protein

ASJC Scopus subject areas

Materials Science(all)

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10.1016/j.stam.2005.11.024

Cite this

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title = "Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers",

abstract = "The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substituent into anthracene core skeleton.",

keywords = "Anthracene, Carbohydrate, Cleavage, Photoirradiation, Hybrid, Protein",

author = "Masashi Hasegawa and Akane Suzuki and Shuichi Matsumura and Kazunobu Toshima",

note = "Funding Information: The authors gratefully acknowledge a Grant-in-Aid for the 21st Century COE Program {\textquoteleft}KEIO Life Conjugate Chemistry{\textquoteright} and for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. We also thank Prof. Shigeru Nishiyama and Mr Takahisa Ogamino, Keio University for measuring HRMS.",

year = "2006",

month = mar,

doi = "10.1016/j.stam.2005.11.024",

language = "English",

volume = "7",

pages = "169--174",

journal = "Science and Technology of Advanced Materials",

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publisher = "IOP Publishing Ltd.",

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TY - JOUR

T1 - Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers

AU - Hasegawa, Masashi

AU - Suzuki, Akane

AU - Matsumura, Shuichi

AU - Toshima, Kazunobu

N1 - Funding Information: The authors gratefully acknowledge a Grant-in-Aid for the 21st Century COE Program ‘KEIO Life Conjugate Chemistry’ and for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. We also thank Prof. Shigeru Nishiyama and Mr Takahisa Ogamino, Keio University for measuring HRMS.

PY - 2006/3

Y1 - 2006/3

N2 - The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substituent into anthracene core skeleton.

AB - The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substituent into anthracene core skeleton.

KW - Anthracene

KW - Carbohydrate

KW - Cleavage

KW - Photoirradiation, Hybrid

KW - Protein

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DO - 10.1016/j.stam.2005.11.024

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VL - 7

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JO - Science and Technology of Advanced Materials

JF - Science and Technology of Advanced Materials

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ER -

Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers

Abstract

Keywords

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