Molecular dynamics study on structual change in the surface membrane of an insonified coated microbubble

F. Ueki, S. Ito, K. Z. Takahashi, Kenji Yasuoka, Toshihiko Sugiura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Coated microbubbles used as ultrasound contrast agents show complicated nonlinear oscillation if insonified. The Marmottant model assumes the experimental surface tension that changes with the bubble radius. Though this model has been widely used in recent years, its physical background is still unclear. In this work, we focused on the molecular level state of the membrane of a coated microbubbles and performed molecular dynamics (MD) simulations of a water-membrane-gas interfacial system. For efficient calculations, the Coarse-Grained (CG) model was used. In this model, the group of atoms is replaced by one effective particle. The calculation efficiency is greatly improved, because the computational cost for interaction calculations is proportional to the power of the number of particles. We obtained stable structures of amphiphilic membrane molecules at different membrane surface densities that are related to the bubble size. The results of membrane thicknesses show qualitative change of the membrane state, and imply the possibility of the phase transition.

Original languageEnglish
Title of host publicationIEEE International Ultrasonics Symposium, IUS
Pages2282-2285
Number of pages4
DOIs
Publication statusPublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 2012 Oct 72012 Oct 10

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period12/10/712/10/10

Fingerprint

molecular dynamics
membranes
bubbles
interfacial tension
costs
oscillations
radii
gases
water
atoms
molecules
simulation
interactions

Keywords

  • bubble dynamics
  • coated microbubble
  • molecular dynamics simulation

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Ueki, F., Ito, S., Takahashi, K. Z., Yasuoka, K., & Sugiura, T. (2012). Molecular dynamics study on structual change in the surface membrane of an insonified coated microbubble. In IEEE International Ultrasonics Symposium, IUS (pp. 2282-2285). [6562339] https://doi.org/10.1109/ULTSYM.2012.0570

Molecular dynamics study on structual change in the surface membrane of an insonified coated microbubble. / Ueki, F.; Ito, S.; Takahashi, K. Z.; Yasuoka, Kenji; Sugiura, Toshihiko.

IEEE International Ultrasonics Symposium, IUS. 2012. p. 2282-2285 6562339.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ueki, F, Ito, S, Takahashi, KZ, Yasuoka, K & Sugiura, T 2012, Molecular dynamics study on structual change in the surface membrane of an insonified coated microbubble. in IEEE International Ultrasonics Symposium, IUS., 6562339, pp. 2282-2285, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 12/10/7. https://doi.org/10.1109/ULTSYM.2012.0570
Ueki, F. ; Ito, S. ; Takahashi, K. Z. ; Yasuoka, Kenji ; Sugiura, Toshihiko. / Molecular dynamics study on structual change in the surface membrane of an insonified coated microbubble. IEEE International Ultrasonics Symposium, IUS. 2012. pp. 2282-2285
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