Molecular embryology for an understanding of congenital heart diseases

Hiroyuki Yamagishi, Jun Maeda, Keiko Uchida, Takatoshi Tsuchihashi, Maki Nakazawa, Megumi Aramaki, Kazuki Kodo, Chihiro Yamagishi

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Congenital heart diseases (CHD) result from abnormal morphogenesis of the embryonic cardiovascular system and usually involve defects in specific structural components of the developing heart and vessels. Therefore, an understanding of "Molecular Embryology", with specific focus on the individual modular steps involved in cardiovascular morphogenesis, is particularly relevant to those wishing to have a better insight into the origin of CHD. Recent advances in molecular embryology suggest that the cardiovascular system arises from multiple distinct embryonic origins, and a population of myocardial precursor cells in the pharyngeal mesoderm anterior to the early heart tube, denoted the "second heart field", has been identified. Discovery of the second heart field has important implications for the interpretation of cardiac outflow tract development and provides new insights into the morphogenesis of CHD.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalAnatomical Science International
Volume84
Issue number3
DOIs
Publication statusPublished - 2009 Apr 8

Keywords

  • Forkhead
  • Heart development
  • IP receptor
  • Second heart field
  • Tbx1

ASJC Scopus subject areas

  • Anatomy

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