Molecular insights into the mechanisms of M-cell differentiation and transcytosis in the mucosa-associated lymphoid tissues

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Microfold cells (M cells), which are located in the follicle-associated epithelium (FAE) covering mucosal lymphoid follicles, are specialized epithelial cells that initiate mucosal immune responses. These cells take luminal antigens and transport them via transcytosis across the FAE to the antigen-presenting cells underneath. Several intestinal pathogens exploit M cells as their portal for entry to invade the host and cause disease conditions. Recent studies have revealed that the uptake of antigens by M cells is essential for efficient antigen-specific IgA production and that this process likely maintains the homeostasis of mucosal tissues. The present article reviews recent advances in understanding the molecular mechanism of M-cell differentiation and describes the molecules expressed by M cells that are associated with antigen uptake and/or the transcytosis process. Current efforts to augment M-cell-mediated uptake for use in the development of effective mucosal vaccines are also discussed.

Original languageEnglish
Pages (from-to)23-34
Number of pages12
JournalAnatomical Science International
Volume93
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

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Transcytosis
Lymphoid Tissue
Cell Differentiation
Mucous Membrane
Antigens
Epithelium
Mucosal Immunity
Antigen-Presenting Cells
Immunoglobulin A
Homeostasis
Vaccines
Epithelial Cells

Keywords

  • Microfold cells
  • Mucosal vaccine
  • Nasal-associated lymphoid tissue
  • Peyer’s patches
  • RANK ligand

ASJC Scopus subject areas

  • Anatomy

Cite this

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abstract = "Microfold cells (M cells), which are located in the follicle-associated epithelium (FAE) covering mucosal lymphoid follicles, are specialized epithelial cells that initiate mucosal immune responses. These cells take luminal antigens and transport them via transcytosis across the FAE to the antigen-presenting cells underneath. Several intestinal pathogens exploit M cells as their portal for entry to invade the host and cause disease conditions. Recent studies have revealed that the uptake of antigens by M cells is essential for efficient antigen-specific IgA production and that this process likely maintains the homeostasis of mucosal tissues. The present article reviews recent advances in understanding the molecular mechanism of M-cell differentiation and describes the molecules expressed by M cells that are associated with antigen uptake and/or the transcytosis process. Current efforts to augment M-cell-mediated uptake for use in the development of effective mucosal vaccines are also discussed.",
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