Molecular mechanism of cell death induced by chemotherapeutic agents

Research output: Contribution to journalArticle

Abstract

Cells maintain their homeostasis by checkpoint mechanisms that exist at each phase of the cell cycle. Impairment of the checkpoint mechanisms induces DNA mutation and asymmetric segregation of chromosomes, which result in genomic instability, leading to malignant cell transformation. DNA-damaging agents, which are still the first-line chemotherapeutic drugs for various cancers, have recently been demonstrated to induce death in cancer cells alone just because these cells have abnormalities in their checkpoint mechanisms. The mitotic checkpoint, in particular, has been found to play a key role in the drug-induced cell death. An understanding of the molecular mechanisms of chemotherapy will enable us to use conventional drugs more appropriately for cancer treatment.

Original languageEnglish
Pages (from-to)843-847
Number of pages5
JournalBrain and Nerve
Volume61
Issue number7
Publication statusPublished - 2009 Jul

Fingerprint

Cell Death
Pharmaceutical Preparations
M Phase Cell Cycle Checkpoints
Neoplasms
Chromosome Segregation
Genomic Instability
DNA
Cell Cycle
Homeostasis
Drug Therapy
Mutation
Therapeutics

Keywords

  • Cell cycle
  • Checkpoint
  • Chemotherapeutic agents
  • Mitotic death

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Molecular mechanism of cell death induced by chemotherapeutic agents. / Saya, Hideyuki.

In: Brain and Nerve, Vol. 61, No. 7, 07.2009, p. 843-847.

Research output: Contribution to journalArticle

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