Molecular mechanism regulating effect of anti-cancer agents

Research output: Contribution to journalReview article

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Abstract

Faithful genome duplication is achieved by accurate coordination between DNA replication and chromosome segregation. Abnormalities occurring in this process are checked by biochemical signal transduction pathways, called checkpoints, which ensure the orderly progression of events in the cell cycle. Checkpoints prevent transition into subsequent phases until all processes in the previous phase are completed. Defects in cell cycle checkpoints result in gene mutations, chromosome damage, and aneuploidy, all of which contribute to tumorigenesis. However, it has recently been uncovered that the impairment of checkpoint function is the major reason why DNA damaging anti-cancer agents can selectively kill cancer cells. Given that G1 and G2 checkpoint functions are generally impaired in cancer cells, cells with DNA damage are unable to maintain G2 arrest and eventually die as they enter mitosis. This process is known as mitotic catastrophe.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume36
Issue number1
Publication statusPublished - 2009 Jan

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Keywords

  • Cell cycle
  • DNA damaging anti-cancer agents
  • Mitotic catastrophe
  • Mitotic death

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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