Abstract
Platinum agents are widely used in current clinical. They exhibit different features, especially in nephrotoxicity, although their toxicological mechanisms are similar. Transporter mediates target delivery of drugs, according to the substrate specificity, tissue distribution and functional characteristics. Recent findings showed that Organic cation transporter OCT and Multidrug and toxin extrusion MATE play important roles in drug delivery of platinum agents. This manuscript summarized topics of delivery of platinum agents to the cancer and kidney via transporters.
| Original language | English |
|---|---|
| Pages (from-to) | 381-388 |
| Number of pages | 8 |
| Journal | Drug Delivery System |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 |
| Externally published | Yes |
Keywords
- Cancer
- Kidney
- Multidrug and toxin extrusion MATE
- Organic cation transporter OCT
- Platinum agent
ASJC Scopus subject areas
- Pharmaceutical Science
