Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism

Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto, Kunio Takaoka, Shigeaki Kato

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalJournal of Bone and Mineral Metabolism
Volume27
Issue number2
DOIs
Publication statusPublished - 2009 Mar
Externally publishedYes

Fingerprint

Minerals
Steroids
Bone and Bones
Gene Targeting
Steroid Receptors
Hematopoiesis
Cytoplasmic and Nuclear Receptors
Osteogenesis
Homeostasis
Calcium
Technology

Keywords

  • Androgen receptor
  • Estrogen receptor
  • Osteoclast
  • Osteoporosis
  • Sex steroid hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism. / Imai, Yuuki; Nakamura, Takashi; Matsumoto, Takahiro; Takaoka, Kunio; Kato, Shigeaki.

In: Journal of Bone and Mineral Metabolism, Vol. 27, No. 2, 03.2009, p. 127-130.

Research output: Contribution to journalReview article

Imai, Yuuki ; Nakamura, Takashi ; Matsumoto, Takahiro ; Takaoka, Kunio ; Kato, Shigeaki. / Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism. In: Journal of Bone and Mineral Metabolism. 2009 ; Vol. 27, No. 2. pp. 127-130.
@article{675de82bd73e476b97ed8344393c96a4,
title = "Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism",
abstract = "The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.",
keywords = "Androgen receptor, Estrogen receptor, Osteoclast, Osteoporosis, Sex steroid hormone",
author = "Yuuki Imai and Takashi Nakamura and Takahiro Matsumoto and Kunio Takaoka and Shigeaki Kato",
year = "2009",
month = "3",
doi = "10.1007/s00774-008-0021-y",
language = "English",
volume = "27",
pages = "127--130",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism

AU - Imai, Yuuki

AU - Nakamura, Takashi

AU - Matsumoto, Takahiro

AU - Takaoka, Kunio

AU - Kato, Shigeaki

PY - 2009/3

Y1 - 2009/3

N2 - The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.

AB - The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.

KW - Androgen receptor

KW - Estrogen receptor

KW - Osteoclast

KW - Osteoporosis

KW - Sex steroid hormone

UR - http://www.scopus.com/inward/record.url?scp=60849135388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60849135388&partnerID=8YFLogxK

U2 - 10.1007/s00774-008-0021-y

DO - 10.1007/s00774-008-0021-y

M3 - Review article

VL - 27

SP - 127

EP - 130

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 2

ER -