Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I

Nicholas P. Restifo, Yutaka Kawakami, Franco Marincola, Peter Shamamian, Akash Taggarse, Fernando Esquivel, Steven A. Rosenberg

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

In this article, we explore the hypothesis that tumor cells can escape recognition by CD8+T cells via deficiencies in antigen processing and presentation. Aspects of the molecular and cellular biology of major histocompatibility complex class I are reviewed. Evidence for histology-specific molecular mechanisms in the antigen-processing and -presentation deficiencies observed in some human and murine tumors is presented. Mechanisms identified include down-regulation of antigen processing, loss of functional β2-microglobulin, and deletion of specific α-chain alleles. Finally, we discuss studies using an antigen-presentation-deficient mouse tumor as a model for the immunogenetherapy of an antigen-presentation deficiency.

Original languageEnglish
Pages (from-to)182-190
Number of pages9
JournalJournal of Immunotherapy
Volume14
Issue number3
DOIs
Publication statusPublished - 1993 Oct

Keywords

  • Antigen presentation
  • Antigen processing
  • CD8T cells
  • Major histocompatibility complex class I
  • Tumor
  • Vaccinia virus, recombinant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

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