Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I

N. P. Restifo, Yutaka Kawakami, F. Marincola, P. Shamamian, A. Taggarse, F. Esquivel, S. A. Rosenberg

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

In this article, we explore the hypothesis that tumor cells can escape recognition by CD8+ T cells via deficiencies in antigen processing and presentation. Aspects of the molecular and cellular biology of major histocompatibility complex class I are reviewed. Evidence for histology- specific molecular mechanisms in the antigen-processing and -presentation deficiencies observed in some human and murine tumors is presented. Mechanisms identified include down-regulation of antigen processing, loss of functional β2-microglobulin, and deletion of specific α-chain alleles. Finally, we discuss studies using an antigen-presentation-deficient mouse tumor as a model for the immunogenetherapy of an antigen-presentation deficiency.

Original languageEnglish
Pages (from-to)182-190
Number of pages9
JournalJournal of Immunotherapy
Volume14
Issue number3
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Tumor Escape
Antigen Presentation
Major Histocompatibility Complex
Cell Biology
Neoplasms
Molecular Biology
Histology
Down-Regulation
Alleles
T-Lymphocytes

Keywords

  • Antigen presentation
  • Antigen processing
  • CD8 T cells
  • Major histocompatibility complex class I
  • Tumor
  • Vaccinia virus, recombinant

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • Pharmacology

Cite this

Restifo, N. P., Kawakami, Y., Marincola, F., Shamamian, P., Taggarse, A., Esquivel, F., & Rosenberg, S. A. (1993). Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I. Journal of Immunotherapy, 14(3), 182-190.

Molecular mechanisms used by tumors to escape immune recognition : Immunogenetherapy and the cell biology of major histocompatibility complex class I. / Restifo, N. P.; Kawakami, Yutaka; Marincola, F.; Shamamian, P.; Taggarse, A.; Esquivel, F.; Rosenberg, S. A.

In: Journal of Immunotherapy, Vol. 14, No. 3, 1993, p. 182-190.

Research output: Contribution to journalArticle

Restifo, NP, Kawakami, Y, Marincola, F, Shamamian, P, Taggarse, A, Esquivel, F & Rosenberg, SA 1993, 'Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I', Journal of Immunotherapy, vol. 14, no. 3, pp. 182-190.
Restifo, N. P. ; Kawakami, Yutaka ; Marincola, F. ; Shamamian, P. ; Taggarse, A. ; Esquivel, F. ; Rosenberg, S. A. / Molecular mechanisms used by tumors to escape immune recognition : Immunogenetherapy and the cell biology of major histocompatibility complex class I. In: Journal of Immunotherapy. 1993 ; Vol. 14, No. 3. pp. 182-190.
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