Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein

Masakazu Ueda, Kyriakos Psarras, Hiromitsu Jinno, Tadashi Ikeda, Kohji Enomoto, Masaki Kitajima, Junichiro Futami, Hidenori Yamada, Masaharu Seno

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins.

Original languageEnglish
Pages (from-to)253-255
Number of pages3
JournalBreast Cancer
Volume4
Issue number4
DOIs
Publication statusPublished - 1997 Dec 1

Keywords

  • Breast cancer
  • EGFR
  • Fusion protein
  • RNase
  • Targeting

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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  • Cite this

    Ueda, M., Psarras, K., Jinno, H., Ikeda, T., Enomoto, K., Kitajima, M., Futami, J., Yamada, H., & Seno, M. (1997). Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein. Breast Cancer, 4(4), 253-255. https://doi.org/10.1007/BF02966516