Monitoring of laser and freezing-induced ablation in the liver with T1-weighted MR imaging.

R. Matsumoto, Koichi Oshio, F. A. Jolesz

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

During both interstitial laser ablation therapy and cryoablation therapy for liver tumors, real-time monitoring is necessary for assessment of ongoing thermal effects in tissue. With single-section images obtained every 30 seconds with a T1-weighted RARE (rapid acquisition with relaxation enhancement) sequence, signal intensity changes in both ex vivo and in vivo animal liver were readily seen. The reversible loss of signal intensity that took place during laser irradiation and the increased intensity at the beginning of cooling can be explained mainly by altered T1 due to temperature change. The frozen area was seen as a sudden decrease in signal intensity at 0 degrees C due to a T2 decrease. This preliminary work showed that the protocol provides enough temporal and temperature resolution to accurately depict the extent of thermal damage, as confirmed at histologic examination. Signal intensity decreased linearly with temperature in the range 10 degrees C-50 degrees C, yielding a pixel-to-pixel temperature resolution of 5.37 degrees C.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalJournal of magnetic resonance imaging : JMRI
Volume2
Issue number5
Publication statusPublished - 1992 Sep
Externally publishedYes

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Freezing
Lasers
Temperature
Liver
Laser Therapy
Hot Temperature
Cryosurgery
Protein Sorting Signals
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Monitoring of laser and freezing-induced ablation in the liver with T1-weighted MR imaging. / Matsumoto, R.; Oshio, Koichi; Jolesz, F. A.

In: Journal of magnetic resonance imaging : JMRI, Vol. 2, No. 5, 09.1992, p. 555-562.

Research output: Contribution to journalArticle

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