質量分析イメージングによる脳内モノアミン新規集積領域の同定

Translated title of the contribution: Monoamine mapping using mass spectrometry identified new monoamine-rich brain nuclei

Eiji Sugiyama, Yuki Sugiura

Research output: Contribution to journalArticlepeer-review

Abstract

Monoamine neurotransmitters are released by specialized neurons that regulate behavioral and cognitive functions. Although localization of monoaminergic neurons in the brain is well known, the distribution, concentration, and kinetics of monoamines remain unclear. We used mass spectrometry imaging (MSI) for simultaneous and quantitative imaging of endogenous monoamines to generate a murine brain atlas of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) levels. We observed several nuclei rich in both 5-HT and a catecholamine (DA or NE). Additionally, we analyzed de novo monoamine synthesis or fluctuations in those nuclei. We propose that MSI is a useful tool to gain deeper understanding of associations among the localization, levels, and turnover of monoamines in different brain areas and their role in inducing behavioral changes.

Translated title of the contributionMonoamine mapping using mass spectrometry identified new monoamine-rich brain nuclei
Original languageChinese (Traditional)
Pages (from-to)979-983
Number of pages5
JournalYakugaku Zasshi
Volume140
Issue number8
DOIs
Publication statusPublished - 2020

Keywords

  • Brain
  • Imaging
  • Kinetics
  • Mass spectrometry
  • Metabolism
  • Monoamine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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