Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development

Chalm O. Jacob, Sadakazu Aiso, Robert D. Schreiber, Hugh O. Mcdevitt

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In attempt to evaluate biological roles of tumor necrosis factor (TNF), we studied the effects of anti-TNF mAb in non-obese diabetic (NOD) mice. Anti-murine TNF mAb rendered NOD mice hypersensitive to the lethal effects of radiation and prevented the reconstitution of lethally Irradiated mice with adoptively transferred lymphocytes. While TNF-α reduced the incidence of diabetes development in the adoptive transfer system even when given 6 days post-transfer, mAb to TNF could not reduce or increase the incidence of diabetes compared to control mice. Administration of TNF-α for 4 or 8 weeks significantly reduced the Incidence of spontaneous Insulitis in NOD mice, while antl-TNF mAb given for 8 weeks Increased the Incidence of insulltls significantly.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalInternational immunology
Volume4
Issue number5
DOIs
Publication statusPublished - 1992 May 1

Keywords

  • Autoimmune diabetes
  • IFN-γ
  • NOD mice
  • Radioprotection
  • TNF-α
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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