Monoclonal antibodies recognising pol and env proteins of mammalian retroviruses

Naoyuki Nishimura, Shingo Kato, Hiromichi Ishikawa, Toshiya Takano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Mouse monoclonal antibodies were generated for three 20- to 23-mer synthetic peptides whose amino acid sequences were highly conserved in the pol or env regions of 14 mammalian and two avian retroviruses. By Western-blot analysis, these antibodies recognised the epitopes in major and minor pol or env proteins of six mammalian type-C and -D retroviruses. One of the anti-env monoclonal antibodies was found to recognise all the env transmembrane proteins of six mammalian retroviruses examined.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalIntervirology
Volume34
Issue number2
DOIs
Publication statusPublished - 1992 Jan 1

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Keywords

  • Baboon endogenous virus
  • Env protein
  • Human retrovirus
  • Monoclonal antibody
  • Pol protein
  • Retrovirus
  • Western-blot analysis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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