Monodisperse microspheres exhibiting discontinuous response to temperature change

Hiroshi Matsuoka, Keiji Fujimoto, Haruma Kawaguchi

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Poly(N-isopropylacrylamide) (PNIPAM) microspheres prepared so far did not exhibit discontinuous change in their properties at the lower critical solution temperature of PNIPAM. In order to create novel microspheres which have sharp temperature-responsiveness, we prepared several kinds of microspheres which had different structures of the thermosensitive shell. Among them, the microspheres whose shell was composed of acrylic acid (AAc)-containing hairy PNIPAM met our requirement, that is, incorporation of only 0.02% AAc into hairy PNIPAM shell was found to enable the properties of microspheres such as hydrodynamic size and electrophoretic mobility to change discontinuously at the critical temperature.

Original languageEnglish
Pages (from-to)319-332
Number of pages14
JournalPolymer Gels and Networks
Issue number5
Publication statusPublished - 1998 Oct

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Pharmaceutical Science
  • Polymers and Plastics


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