Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi; Keisuke Ichinohe; Shinya Kida; Shinya Murase; Osamu Yamada; Yoshiteru Oshima

doi:10.1021/acs.orglett.6b03057

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi, Keisuke Ichinohe, Shinya Kida, Shinya Murase, Osamu Yamada, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

Original language	English
Pages (from-to)	5948-5951
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.6b03057
Publication status	Published - 2016 Nov 18
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity. / Kikuchi, Haruhisa; Ichinohe, Keisuke; Kida, Shinya; Murase, Shinya; Yamada, Osamu; Oshima, Yoshiteru.

In: Organic Letters, Vol. 18, No. 22, 18.11.2016, p. 5948-5951.

Research output: Contribution to journal › Article › peer-review

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abstract = "A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.",

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AU - Kida, Shinya

AU - Murase, Shinya

AU - Yamada, Osamu

AU - Oshima, Yoshiteru

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Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Abstract

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