Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi; Keisuke Ichinohe; Shinya Kida; Shinya Murase; Osamu Yamada; Yoshiteru Oshima

doi:10.1021/acs.orglett.6b03057

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi, Keisuke Ichinohe, Shinya Kida, Shinya Murase, Osamu Yamada, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

Original language	English
Pages (from-to)	5948-5951
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.6b03057
Publication status	Published - 2016 Nov 18
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.6b03057

Cite this

@article{3240874f0f124b4982f566175f02496b,

title = "Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity",

abstract = "A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.",

author = "Haruhisa Kikuchi and Keisuke Ichinohe and Shinya Kida and Shinya Murase and Osamu Yamada and Yoshiteru Oshima",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = nov,

day = "18",

doi = "10.1021/acs.orglett.6b03057",

language = "English",

volume = "18",

pages = "5948--5951",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "22",

}

TY - JOUR

T1 - Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

AU - Kikuchi, Haruhisa

AU - Ichinohe, Keisuke

AU - Kida, Shinya

AU - Murase, Shinya

AU - Yamada, Osamu

AU - Oshima, Yoshiteru

PY - 2016/11/18

Y1 - 2016/11/18

N2 - A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

AB - A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

UR - http://www.scopus.com/inward/record.url?scp=84996566971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996566971&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.6b03057

DO - 10.1021/acs.orglett.6b03057

M3 - Article

AN - SCOPUS:84996566971

VL - 18

SP - 5948

EP - 5951

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 22

ER -

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this