Abstract
A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.
Original language | English |
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Pages (from-to) | 5948-5951 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 18 |
Issue number | 22 |
DOIs | |
Publication status | Published - 2016 Nov 18 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry