Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice

Hiroki Iwata, Shizuko Tsuchiya, Koichi Ueno, Tomonori Nakamura, Shingo Yano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.

Original languageEnglish
Pages (from-to)130-132
Number of pages3
JournalEuropean journal of pharmacology
Volume600
Issue number1-3
DOIs
Publication statusPublished - 2008 Dec 14
Externally publishedYes

Keywords

  • Circular muscle contraction
  • Morphine
  • Morphine-3-glucuronide
  • Morphine-6-glucuronide
  • Mouse ileum

ASJC Scopus subject areas

  • Pharmacology

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