Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice

Hiroki Iwata; Shizuko Tsuchiya; Koichi Ueno; Tomonori Nakamura; Shingo Yano

doi:10.1016/j.ejphar.2008.10.009

Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice

Hiroki Iwata, Shizuko Tsuchiya, Koichi Ueno, Tomonori Nakamura, Shingo Yano

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.

Original language	English
Pages (from-to)	130-132
Number of pages	3
Journal	European journal of pharmacology
Volume	600
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2008.10.009
Publication status	Published - 2008 Dec 14
Externally published	Yes

Keywords

Circular muscle contraction
Morphine
Morphine-3-glucuronide
Morphine-6-glucuronide
Mouse ileum

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2008.10.009

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title = "Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice",

abstract = "It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.",

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AU - Iwata, Hiroki

AU - Tsuchiya, Shizuko

AU - Ueno, Koichi

AU - Nakamura, Tomonori

AU - Yano, Shingo

PY - 2008/12/14

Y1 - 2008/12/14

N2 - It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.

AB - It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.

KW - Circular muscle contraction

KW - Morphine

KW - Morphine-3-glucuronide

KW - Morphine-6-glucuronide

KW - Mouse ileum

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Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice

Abstract

Keywords

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