Morphological variation of hydroxyapatite grown in aqueous solution based on simulated body fluid

Toru Kobayashi, Shohei Ono, Sho Hirakura, Yuya Oaki, Hiroaki Imai

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33 Citations (Scopus)


We successfully controlled the morphology of hydroxyapatite (HAp) grown in a solution system based on simulated body fluid (SBF). Nanometric low-dimensional forms, such as sheets and needles elongated in the c axis, were produced with phosphate-surplus (or calcium-deficient) HAp in the solution at human body temperature. The nanoneedles were obtained on the seed crystals under gentle growth conditions at pH 6.5; the nanosheets were grown through coalescence of tiny grains or needles at a relatively high growth rate above pH 7.0. On the other hand, micrometric bulky hexagonal shapes and faceted plates of semi-stoichiometric HAp were grown under hydrothermal conditions at pH 7.0 and 7.4, respectively. The variation of the morphology is discussed on the basis of the change of the growth mode of HAp crystals depending on the supersaturated conditions.

Original languageEnglish
Pages (from-to)1143-1149
Number of pages7
Issue number3
Publication statusPublished - 2012 Feb 7


ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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