Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions

Toshinori Sato, Mineo Hashizume, Yasunobu Hotta, Yoshio Okahata

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38 Citations (Scopus)


The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM, B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions, B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1, to S state.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
Issue number2
Publication statusPublished - 1998 Apr 8



  • Aluminium ion
  • B16 melanoma cell
  • Lanthanoid
  • Morphology
  • Proliferation

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

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