Mortality, morbidity, and failure to rescue in hepatopancreatoduodenectomy: An analysis of patients registered in the National Clinical Database in Japan

Itaru Endo, Norimichi Hirahara, Hiroaki Miyata, Hiroyuki Yamamoto, Ryusei Matsuyama, Takafumi Kumamoto, Yuki Homma, Masaki Mori, Yasuyuki Seto, Go Wakabayashi, Yuko Kitagawa, Fumihiko Miura, Norihiro Kokudo, Tomoo Kosuge, Masato Nagino, Akihiko Horiguchi, Satoshi Hirano, Hiroki Yamaue, Masakazu Yamamoto, Masaru Miyazaki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: The high operative mortality rate after hepatopancreatoduodenectomy (HPD) is still a major issue. The present study explored why operative mortality differs significantly due to hospital volume. Method: Surgical case data were extracted from the National Clinical Database (NCD) in Japan from 2011 to 2014. Surgical procedures were categorized as major (≥2 sections) and minor (<2 sections) hepatectomy. Hospitals were categorized according to the certification system by the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS) based on the number of major hepato-biliary-pancreatic surgeries performed per year. The FTR rate was defined as death in a patient with at least one postoperative complication. Results: A total of 422 patients who underwent HPD were analyzed. The operative mortality rates in board-certified A training institutions, board-certified B training institutions, and non-certified institution were 7.2%, 11.6%, and 21.4%, respectively. Multiple logistic regression showed that certified A institutions, major hepatectomy, and blood transfusion were the predictors of operative mortality. Failure to rescue rates were lowest in certified A institutions (9.3%, 17.0%, and 33.3% in certified A, certified B, and non-certified, respectively). Conclusions: To reduce operative mortality after HPD, further centralization of this procedure is desirable. Future studies should clarify specific ways to improve the failure-to-rescue rates in certified institutions.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume28
Issue number4
DOIs
Publication statusPublished - 2021 Apr
Externally publishedYes

Keywords

  • National Clinical Database
  • extent of liver resection
  • failure to rescue
  • hospital volume
  • operative mortality

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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