Mortality risk attributable to atrial fibrillation in middle-aged and elderly people in the Japanese general population - Nineteen-year follow-up in NIPPON DATA80

Masaki Ohsawa, Akira Okayama, Tomonori Okamura, Kazuyoshi Itai, Motoyuki Nakamura, Kozo Tanno, Karen Kato, Yumi Yaegashi, Toshiyuki Onoda, Kiyomi Sakata, Hirotsugu Ueshima

Research output: Contribution to journalArticle

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Abstract

Background: The extent to which atrial fibrillation (AF) contributes to mortality in the Japanese general population has not been clarified. Methods and Results: A randomly sampled general population from all over Japan (4,154 men, 5,329 women; age ≥30 years) was enrolled. Single electrocardiogram recordings were taken in the baseline survey. Stroke death, cardiovascular deaths and all-cause deaths during the subsequent 19 years were analyzed by the presence of AF at baseline. Cox's regression analysis was carried out to estimate the hazard ratios (HRs) of each cause of death attributable to AF after adjusting for other risk factors. Prevalence of AF was 0.64% in the study. The observed person-years were 162,980 among persons without AF and 699 among persons with AF. There were 1,919 deaths. Multivariate adjusted HRs for stroke death, cardiovascular death and all-cause death were 2.69, 2.76 and 1.88, respectively (p<0.05). These HRs were 14.7, 9.63 and 4.00 among persons aged 64 years or younger (p<0.05). Conclusion: AF affects stroke mortality, cardiovascular mortality and all-cause mortality in the Japanese general population. Careful attention should be paid to persons with AF in order to prevent future cardiovascular events.

Original languageEnglish
Pages (from-to)814-819
Number of pages6
JournalCirculation Journal
Volume71
Issue number6
DOIs
Publication statusPublished - 2007
Externally publishedYes

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Atrial Fibrillation
Mortality
Population
Cause of Death
Myocardial Infarction
Japan
Electrocardiography
Regression Analysis

Keywords

  • Atrial fibrillation
  • Japanese
  • Mortality
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Mortality risk attributable to atrial fibrillation in middle-aged and elderly people in the Japanese general population - Nineteen-year follow-up in NIPPON DATA80. / Ohsawa, Masaki; Okayama, Akira; Okamura, Tomonori; Itai, Kazuyoshi; Nakamura, Motoyuki; Tanno, Kozo; Kato, Karen; Yaegashi, Yumi; Onoda, Toshiyuki; Sakata, Kiyomi; Ueshima, Hirotsugu.

In: Circulation Journal, Vol. 71, No. 6, 2007, p. 814-819.

Research output: Contribution to journalArticle

Ohsawa, Masaki ; Okayama, Akira ; Okamura, Tomonori ; Itai, Kazuyoshi ; Nakamura, Motoyuki ; Tanno, Kozo ; Kato, Karen ; Yaegashi, Yumi ; Onoda, Toshiyuki ; Sakata, Kiyomi ; Ueshima, Hirotsugu. / Mortality risk attributable to atrial fibrillation in middle-aged and elderly people in the Japanese general population - Nineteen-year follow-up in NIPPON DATA80. In: Circulation Journal. 2007 ; Vol. 71, No. 6. pp. 814-819.
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T1 - Mortality risk attributable to atrial fibrillation in middle-aged and elderly people in the Japanese general population - Nineteen-year follow-up in NIPPON DATA80

AU - Ohsawa, Masaki

AU - Okayama, Akira

AU - Okamura, Tomonori

AU - Itai, Kazuyoshi

AU - Nakamura, Motoyuki

AU - Tanno, Kozo

AU - Kato, Karen

AU - Yaegashi, Yumi

AU - Onoda, Toshiyuki

AU - Sakata, Kiyomi

AU - Ueshima, Hirotsugu

PY - 2007

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N2 - Background: The extent to which atrial fibrillation (AF) contributes to mortality in the Japanese general population has not been clarified. Methods and Results: A randomly sampled general population from all over Japan (4,154 men, 5,329 women; age ≥30 years) was enrolled. Single electrocardiogram recordings were taken in the baseline survey. Stroke death, cardiovascular deaths and all-cause deaths during the subsequent 19 years were analyzed by the presence of AF at baseline. Cox's regression analysis was carried out to estimate the hazard ratios (HRs) of each cause of death attributable to AF after adjusting for other risk factors. Prevalence of AF was 0.64% in the study. The observed person-years were 162,980 among persons without AF and 699 among persons with AF. There were 1,919 deaths. Multivariate adjusted HRs for stroke death, cardiovascular death and all-cause death were 2.69, 2.76 and 1.88, respectively (p<0.05). These HRs were 14.7, 9.63 and 4.00 among persons aged 64 years or younger (p<0.05). Conclusion: AF affects stroke mortality, cardiovascular mortality and all-cause mortality in the Japanese general population. Careful attention should be paid to persons with AF in order to prevent future cardiovascular events.

AB - Background: The extent to which atrial fibrillation (AF) contributes to mortality in the Japanese general population has not been clarified. Methods and Results: A randomly sampled general population from all over Japan (4,154 men, 5,329 women; age ≥30 years) was enrolled. Single electrocardiogram recordings were taken in the baseline survey. Stroke death, cardiovascular deaths and all-cause deaths during the subsequent 19 years were analyzed by the presence of AF at baseline. Cox's regression analysis was carried out to estimate the hazard ratios (HRs) of each cause of death attributable to AF after adjusting for other risk factors. Prevalence of AF was 0.64% in the study. The observed person-years were 162,980 among persons without AF and 699 among persons with AF. There were 1,919 deaths. Multivariate adjusted HRs for stroke death, cardiovascular death and all-cause death were 2.69, 2.76 and 1.88, respectively (p<0.05). These HRs were 14.7, 9.63 and 4.00 among persons aged 64 years or younger (p<0.05). Conclusion: AF affects stroke mortality, cardiovascular mortality and all-cause mortality in the Japanese general population. Careful attention should be paid to persons with AF in order to prevent future cardiovascular events.

KW - Atrial fibrillation

KW - Japanese

KW - Mortality

KW - Stroke

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