Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, Pho85 kinase

Masafumi Nishizawa, Yuko Kanaya, Akio Toh-e

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Mouse cyclin-dependent kinase (Cdk) 5 and yeast Pho85 kinase share similarities in structure as well as in the regulation of their activity. We found that mouse Cdk5 kinase produced in pho85A mutant cells could suppress some of pho85Δ mutant phenotypes including failure to grow on nonfermentable carbon sources, morphological defects, and growth defect caused by Pho4 or Clb2 overproduction. We also demonstrated that Cdk5 coimmunoprecipitated with Pho85-cyclins including Pc11, Pc12, Pc16, Pc19, and Pho80, and that the immunocomplex could phosphorylate Pho4, a native substrate of Pho85 kinase. Thus mouse Cdk5 is a functional homologue of yeast Pho85 kinase.

Original languageEnglish
Pages (from-to)33859-33862
Number of pages4
JournalJournal of Biological Chemistry
Issue number48
Publication statusPublished - 1999 Nov 26


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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