TY - JOUR
T1 - Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, Pho85 kinase
AU - Nishizawa, Masafumi
AU - Kanaya, Yuko
AU - Toh-e, Akio
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/11/26
Y1 - 1999/11/26
N2 - Mouse cyclin-dependent kinase (Cdk) 5 and yeast Pho85 kinase share similarities in structure as well as in the regulation of their activity. We found that mouse Cdk5 kinase produced in pho85A mutant cells could suppress some of pho85Δ mutant phenotypes including failure to grow on nonfermentable carbon sources, morphological defects, and growth defect caused by Pho4 or Clb2 overproduction. We also demonstrated that Cdk5 coimmunoprecipitated with Pho85-cyclins including Pc11, Pc12, Pc16, Pc19, and Pho80, and that the immunocomplex could phosphorylate Pho4, a native substrate of Pho85 kinase. Thus mouse Cdk5 is a functional homologue of yeast Pho85 kinase.
AB - Mouse cyclin-dependent kinase (Cdk) 5 and yeast Pho85 kinase share similarities in structure as well as in the regulation of their activity. We found that mouse Cdk5 kinase produced in pho85A mutant cells could suppress some of pho85Δ mutant phenotypes including failure to grow on nonfermentable carbon sources, morphological defects, and growth defect caused by Pho4 or Clb2 overproduction. We also demonstrated that Cdk5 coimmunoprecipitated with Pho85-cyclins including Pc11, Pc12, Pc16, Pc19, and Pho80, and that the immunocomplex could phosphorylate Pho4, a native substrate of Pho85 kinase. Thus mouse Cdk5 is a functional homologue of yeast Pho85 kinase.
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U2 - 10.1074/jbc.274.48.33859
DO - 10.1074/jbc.274.48.33859
M3 - Article
C2 - 10567344
AN - SCOPUS:0033607545
SN - 0021-9258
VL - 274
SP - 33859
EP - 33862
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 48
ER -