Mouse myocilin (Myoc) gene expression in ocular tissues

Hiroki Takahashi, Setsuko Noda, Yutaka Imamura, Akemi Nagasawa, Ryo Kubota, Yukihiko Mashima, Jun Kudo, Yoshihisa Oguchi, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Human myocilin is identical to TIGR (trabecular meshwork inducible glucocorticoid response) which is responsible for the pathogenesis of juvenile-onset primary open angle glaucoma (GLC1A). We have isolated cDNA for mouse myocilin (Myoc) and investigated mouse myocilin gene expression in ocular tissues with in situ RNA hybridization. Hybridization signals were observed in the iris, ciliary body, trabecular meshwork, sclera, and retina in the mouse eye. The marked signals were seen in trabecular meshwork cells and the anterior portion of sclera. These findings suggest that myocilin mutation could affect the capacity of aqueous outflow and cause elevation of the intraocular pressure which is involved in the pathogenesis of glaucoma.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume248
Issue number1
DOIs
Publication statusPublished - 1998 Jul 9

Fingerprint

Trabecular Meshwork
Gene expression
Tissue
Gene Expression
Sclera
Ciliary Body
Iris
Intraocular Pressure
Glaucoma
Glucocorticoids
In Situ Hybridization
Retina
Complementary DNA
RNA
Mutation
trabecular meshwork-induced glucocorticoid response protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Takahashi, H., Noda, S., Imamura, Y., Nagasawa, A., Kubota, R., Mashima, Y., ... Shimizu, N. (1998). Mouse myocilin (Myoc) gene expression in ocular tissues. Biochemical and Biophysical Research Communications, 248(1), 104-109. https://doi.org/10.1006/bbrc.1998.8917

Mouse myocilin (Myoc) gene expression in ocular tissues. / Takahashi, Hiroki; Noda, Setsuko; Imamura, Yutaka; Nagasawa, Akemi; Kubota, Ryo; Mashima, Yukihiko; Kudo, Jun; Oguchi, Yoshihisa; Shimizu, Nobuyoshi.

In: Biochemical and Biophysical Research Communications, Vol. 248, No. 1, 09.07.1998, p. 104-109.

Research output: Contribution to journalArticle

Takahashi, H, Noda, S, Imamura, Y, Nagasawa, A, Kubota, R, Mashima, Y, Kudo, J, Oguchi, Y & Shimizu, N 1998, 'Mouse myocilin (Myoc) gene expression in ocular tissues', Biochemical and Biophysical Research Communications, vol. 248, no. 1, pp. 104-109. https://doi.org/10.1006/bbrc.1998.8917
Takahashi H, Noda S, Imamura Y, Nagasawa A, Kubota R, Mashima Y et al. Mouse myocilin (Myoc) gene expression in ocular tissues. Biochemical and Biophysical Research Communications. 1998 Jul 9;248(1):104-109. https://doi.org/10.1006/bbrc.1998.8917
Takahashi, Hiroki ; Noda, Setsuko ; Imamura, Yutaka ; Nagasawa, Akemi ; Kubota, Ryo ; Mashima, Yukihiko ; Kudo, Jun ; Oguchi, Yoshihisa ; Shimizu, Nobuyoshi. / Mouse myocilin (Myoc) gene expression in ocular tissues. In: Biochemical and Biophysical Research Communications. 1998 ; Vol. 248, No. 1. pp. 104-109.
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