Mouse myocilin (Myoc) gene expression in ocular tissues

Hiroki Takahashi, Setsuko Noda, Yutaka Imamura, Akemi Nagasawa, Ryo Kubota, Yukihiko Mashima, Jun Kudoh, Yoshihisa Oguchi, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Human myocilin is identical to TIGR (trabecular meshwork inducible glucocorticoid response) which is responsible for the pathogenesis of juvenile-onset primary open angle glaucoma (GLC1A). We have isolated cDNA for mouse myocilin (Myoc) and investigated mouse myocilin gene expression in ocular tissues with in situ RNA hybridization. Hybridization signals were observed in the iris, ciliary body, trabecular meshwork, sclera, and retina in the mouse eye. The marked signals were seen in trabecular meshwork cells and the anterior portion of sclera. These findings suggest that myocilin mutation could affect the capacity of aqueous outflow and cause elevation of the intraocular pressure which is involved in the pathogenesis of glaucoma.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume248
Issue number1
DOIs
Publication statusPublished - 1998 Jul 9

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Takahashi, H., Noda, S., Imamura, Y., Nagasawa, A., Kubota, R., Mashima, Y., Kudoh, J., Oguchi, Y., & Shimizu, N. (1998). Mouse myocilin (Myoc) gene expression in ocular tissues. Biochemical and Biophysical Research Communications, 248(1), 104-109. https://doi.org/10.1006/bbrc.1998.8917