MPAI (Mass Probes Aided Ionization) method for total analysis of biomolecules by mass spectrometry

Aki Honda, Shinichiro Hayashi, Hiroki Hifumi, Yuya Honma, Noriyuki Tanji, Naoko Iwasawa, Yoshio Suzuki, Koji Suzuki

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

We have designed and synthesized various mass probes, which enable us to effectively ionize various molecules to be detected with mass spectrometry. We call the ionization method using mass probes the "MPAI (mass probes aided ionization)" method. We aim at the sensitive detection of various biological molecules, and also the detection of biomolecules by a single mass spectrometry serially without changing the mechanical settings. Here, we review mass probes for small molecules with various functional groups and mass probes for proteins. Further, we introduce newly developed mass probes for proteins for highly sensitive detection. 2007

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalAnalytical Sciences
Volume23
Issue number1
DOIs
Publication statusPublished - 2007 Jan

ASJC Scopus subject areas

  • Analytical Chemistry

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  • Cite this

    Honda, A., Hayashi, S., Hifumi, H., Honma, Y., Tanji, N., Iwasawa, N., Suzuki, Y., & Suzuki, K. (2007). MPAI (Mass Probes Aided Ionization) method for total analysis of biomolecules by mass spectrometry. Analytical Sciences, 23(1), 11-15. https://doi.org/10.2116/analsci.23.11