MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: Case report

Ryuji Morizane, Konosuke Konishi, Akinori Hashiguchi, Hirobumi Tokuyama, Shu Wakino, Hiroshi Kawabe, Matsuhiko Hayashi, Koichi Hayashi, Hiroshi Itoh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis (CGN) is a major cause of rapidly progressive glomerulonephritis (RPGN). ANCA-associated CGN is generally classified into pauci-immune RPGN, in which there are few or no immune complexes. Case Presentation. A 78-year-old man presented with RPGN after a 7-year course of chronic proteinuria and hematuria with stable renal function. A blood examination showed a high titer of myeloperoxidase (MPO)-ANCA. A renal biopsy showed crescentic glomerulonephritis with abundant subepithelial, intramenbranous and subendothelial deposits by electron microscopy, leading to the diagnosis of ANCA-associated CGN superimposed on type 3 membranoproliferative glomerulonephritis (MPGN). Conclusions: This case is unique in that type 3 MPGN and MPO-ANCA-associated CGN coexisted, and no similar case has been reported to date. Because ANCA-associated CGN has a predilection for elderly individuals and primary type 3 MPGN is rarely seen in this age group, coincidental existence appears less likely. This case may confer valuable information regarding the link between immune complex and ANCA-associated CGN.

Original languageEnglish
Article number32
JournalBMC Nephrology
Volume13
Issue number1
DOIs
Publication statusPublished - 2012

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Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Antigen-Antibody Complex
Peroxidase
Membranoproliferative Glomerulonephritis
Kidney
Hematuria
Proteinuria
Electron Microscopy
Age Groups
Biopsy

Keywords

  • Immune complex
  • Membranoproliferative glomerulonephritis
  • Myeloperoxidase-antineutrophil cytoplasmic antibody
  • Rapidly progressive glomerulonephritis

ASJC Scopus subject areas

  • Nephrology

Cite this

MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes : Case report. / Morizane, Ryuji; Konishi, Konosuke; Hashiguchi, Akinori; Tokuyama, Hirobumi; Wakino, Shu; Kawabe, Hiroshi; Hayashi, Matsuhiko; Hayashi, Koichi; Itoh, Hiroshi.

In: BMC Nephrology, Vol. 13, No. 1, 32, 2012.

Research output: Contribution to journalArticle

Morizane, Ryuji ; Konishi, Konosuke ; Hashiguchi, Akinori ; Tokuyama, Hirobumi ; Wakino, Shu ; Kawabe, Hiroshi ; Hayashi, Matsuhiko ; Hayashi, Koichi ; Itoh, Hiroshi. / MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes : Case report. In: BMC Nephrology. 2012 ; Vol. 13, No. 1.
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