MRI analysis of the combined prospectively collected AOSpine North America and International Data: The Prevalence and Spectrum of Pathologies in a Global Cohort of Patients with Degenerative Cervical Myelopathy

Aria Nouri, Allan Martin, Lindsay Tetreault, Anick Nater, So Kato, Hiroaki Nakashima, Narihito Nagoshi, Hamed Reihani-Kermani, Michael G. Fehlings

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

STUDY DESIGN.: Ambispective Analysis OBJECTIVE.: To report the global prevalence of specific degenerative cervical pathologies in patients with DCM through detailed review of MRIs SUMMARY OF BACKGROUND DATA.: Degenerative Cervical Myelopathy (DCM) encompasses a spectrum of age-related conditions that result in progressive spinal cord injury. METHODS.: MRIs of 458 patients (age 56.4?+/-11.8, 285 Male, 173 Female) patients were reviewed for specific degenerative features, directionality of cord compression, levels of spinal cord compression, and signal changes on T2WI and T1WI. Data were analyzed for differences between sex using Chi-square tests and geographic variations using Kruskal-Wallis tests. RESULTS.: Spondylosis was frequently present (89.7%) and was commonly accompanied by enlargement of the ligamentum flavum (LF) (59.9%). Single level disc pathology, Ossification of posterior longitudinal ligament (OPLL) and spondylolisthesis had a prevalence of ∼10% each. OPLL was accompanied by spondylosis in 91.7%. Klippel-Feil Syndrome was observed in 2.0%. The Asia-Pacific region had more OPLL (29%, p?=?3x10) and less spondylolisthesis (1.9%, p?=?0.002). Females presented more commonly with single level disc pathology (13.9% vs. 6.7%; p?=?0.013), and males with spondylosis (92.3% vs. 85.6%; p?=?0.02) and enlargement of LF (61.4% vs. 49.1%; p?=?0.01). C5–6 was the most frequent maximum compressed site (39.5%) and region for T2WI hyperintensity (38.9%). T2WI hyperintensity more commonly presented in males (82.4% vs. 66.7%; p?<?0.001). CONCLUSION.: This is the largest report on the prevalence and spectrum of pathology in patients with DCM. Herein it has been demonstrated that degenerative features are highly interrelated, that females presented with milder MRI evidence of DCM, and that variations exist in the prevalence of pathologies between geographical regions. LEVEL OF EVIDENCE.: 2.

Original languageEnglish
JournalSpine
DOIs
Publication statusAccepted/In press - 2016 Nov 16
Externally publishedYes

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Spinal Cord Diseases
North America
Ossification of Posterior Longitudinal Ligament
Spondylosis
Pathology
Ligamentum Flavum
Spondylolisthesis
Klippel-Feil Syndrome
Spinal Cord Compression
Chi-Square Distribution
Spinal Cord Injuries
Sex Characteristics

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

MRI analysis of the combined prospectively collected AOSpine North America and International Data : The Prevalence and Spectrum of Pathologies in a Global Cohort of Patients with Degenerative Cervical Myelopathy. / Nouri, Aria; Martin, Allan; Tetreault, Lindsay; Nater, Anick; Kato, So; Nakashima, Hiroaki; Nagoshi, Narihito; Reihani-Kermani, Hamed; Fehlings, Michael G.

In: Spine, 16.11.2016.

Research output: Contribution to journalArticle

Nouri, Aria ; Martin, Allan ; Tetreault, Lindsay ; Nater, Anick ; Kato, So ; Nakashima, Hiroaki ; Nagoshi, Narihito ; Reihani-Kermani, Hamed ; Fehlings, Michael G. / MRI analysis of the combined prospectively collected AOSpine North America and International Data : The Prevalence and Spectrum of Pathologies in a Global Cohort of Patients with Degenerative Cervical Myelopathy. In: Spine. 2016.
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abstract = "STUDY DESIGN.: Ambispective Analysis OBJECTIVE.: To report the global prevalence of specific degenerative cervical pathologies in patients with DCM through detailed review of MRIs SUMMARY OF BACKGROUND DATA.: Degenerative Cervical Myelopathy (DCM) encompasses a spectrum of age-related conditions that result in progressive spinal cord injury. METHODS.: MRIs of 458 patients (age 56.4?+/-11.8, 285 Male, 173 Female) patients were reviewed for specific degenerative features, directionality of cord compression, levels of spinal cord compression, and signal changes on T2WI and T1WI. Data were analyzed for differences between sex using Chi-square tests and geographic variations using Kruskal-Wallis tests. RESULTS.: Spondylosis was frequently present (89.7{\%}) and was commonly accompanied by enlargement of the ligamentum flavum (LF) (59.9{\%}). Single level disc pathology, Ossification of posterior longitudinal ligament (OPLL) and spondylolisthesis had a prevalence of ∼10{\%} each. OPLL was accompanied by spondylosis in 91.7{\%}. Klippel-Feil Syndrome was observed in 2.0{\%}. The Asia-Pacific region had more OPLL (29{\%}, p?=?3x10) and less spondylolisthesis (1.9{\%}, p?=?0.002). Females presented more commonly with single level disc pathology (13.9{\%} vs. 6.7{\%}; p?=?0.013), and males with spondylosis (92.3{\%} vs. 85.6{\%}; p?=?0.02) and enlargement of LF (61.4{\%} vs. 49.1{\%}; p?=?0.01). C5–6 was the most frequent maximum compressed site (39.5{\%}) and region for T2WI hyperintensity (38.9{\%}). T2WI hyperintensity more commonly presented in males (82.4{\%} vs. 66.7{\%}; p?<?0.001). CONCLUSION.: This is the largest report on the prevalence and spectrum of pathology in patients with DCM. Herein it has been demonstrated that degenerative features are highly interrelated, that females presented with milder MRI evidence of DCM, and that variations exist in the prevalence of pathologies between geographical regions. LEVEL OF EVIDENCE.: 2.",
author = "Aria Nouri and Allan Martin and Lindsay Tetreault and Anick Nater and So Kato and Hiroaki Nakashima and Narihito Nagoshi and Hamed Reihani-Kermani and Fehlings, {Michael G.}",
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T2 - The Prevalence and Spectrum of Pathologies in a Global Cohort of Patients with Degenerative Cervical Myelopathy

AU - Nouri, Aria

AU - Martin, Allan

AU - Tetreault, Lindsay

AU - Nater, Anick

AU - Kato, So

AU - Nakashima, Hiroaki

AU - Nagoshi, Narihito

AU - Reihani-Kermani, Hamed

AU - Fehlings, Michael G.

PY - 2016/11/16

Y1 - 2016/11/16

N2 - STUDY DESIGN.: Ambispective Analysis OBJECTIVE.: To report the global prevalence of specific degenerative cervical pathologies in patients with DCM through detailed review of MRIs SUMMARY OF BACKGROUND DATA.: Degenerative Cervical Myelopathy (DCM) encompasses a spectrum of age-related conditions that result in progressive spinal cord injury. METHODS.: MRIs of 458 patients (age 56.4?+/-11.8, 285 Male, 173 Female) patients were reviewed for specific degenerative features, directionality of cord compression, levels of spinal cord compression, and signal changes on T2WI and T1WI. Data were analyzed for differences between sex using Chi-square tests and geographic variations using Kruskal-Wallis tests. RESULTS.: Spondylosis was frequently present (89.7%) and was commonly accompanied by enlargement of the ligamentum flavum (LF) (59.9%). Single level disc pathology, Ossification of posterior longitudinal ligament (OPLL) and spondylolisthesis had a prevalence of ∼10% each. OPLL was accompanied by spondylosis in 91.7%. Klippel-Feil Syndrome was observed in 2.0%. The Asia-Pacific region had more OPLL (29%, p?=?3x10) and less spondylolisthesis (1.9%, p?=?0.002). Females presented more commonly with single level disc pathology (13.9% vs. 6.7%; p?=?0.013), and males with spondylosis (92.3% vs. 85.6%; p?=?0.02) and enlargement of LF (61.4% vs. 49.1%; p?=?0.01). C5–6 was the most frequent maximum compressed site (39.5%) and region for T2WI hyperintensity (38.9%). T2WI hyperintensity more commonly presented in males (82.4% vs. 66.7%; p?<?0.001). CONCLUSION.: This is the largest report on the prevalence and spectrum of pathology in patients with DCM. Herein it has been demonstrated that degenerative features are highly interrelated, that females presented with milder MRI evidence of DCM, and that variations exist in the prevalence of pathologies between geographical regions. LEVEL OF EVIDENCE.: 2.

AB - STUDY DESIGN.: Ambispective Analysis OBJECTIVE.: To report the global prevalence of specific degenerative cervical pathologies in patients with DCM through detailed review of MRIs SUMMARY OF BACKGROUND DATA.: Degenerative Cervical Myelopathy (DCM) encompasses a spectrum of age-related conditions that result in progressive spinal cord injury. METHODS.: MRIs of 458 patients (age 56.4?+/-11.8, 285 Male, 173 Female) patients were reviewed for specific degenerative features, directionality of cord compression, levels of spinal cord compression, and signal changes on T2WI and T1WI. Data were analyzed for differences between sex using Chi-square tests and geographic variations using Kruskal-Wallis tests. RESULTS.: Spondylosis was frequently present (89.7%) and was commonly accompanied by enlargement of the ligamentum flavum (LF) (59.9%). Single level disc pathology, Ossification of posterior longitudinal ligament (OPLL) and spondylolisthesis had a prevalence of ∼10% each. OPLL was accompanied by spondylosis in 91.7%. Klippel-Feil Syndrome was observed in 2.0%. The Asia-Pacific region had more OPLL (29%, p?=?3x10) and less spondylolisthesis (1.9%, p?=?0.002). Females presented more commonly with single level disc pathology (13.9% vs. 6.7%; p?=?0.013), and males with spondylosis (92.3% vs. 85.6%; p?=?0.02) and enlargement of LF (61.4% vs. 49.1%; p?=?0.01). C5–6 was the most frequent maximum compressed site (39.5%) and region for T2WI hyperintensity (38.9%). T2WI hyperintensity more commonly presented in males (82.4% vs. 66.7%; p?<?0.001). CONCLUSION.: This is the largest report on the prevalence and spectrum of pathology in patients with DCM. Herein it has been demonstrated that degenerative features are highly interrelated, that females presented with milder MRI evidence of DCM, and that variations exist in the prevalence of pathologies between geographical regions. LEVEL OF EVIDENCE.: 2.

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