MRI signal intensity based B-spline nonrigid registration for pre- and intraoperative imaging during prostate brachytherapy

Sota Oguro, Junichi Tokuda, Haytham Elhawary, Steven Haker, Ron Kikinis, Clare M C Tempany, Nobuhiko Hata

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Purpose: To apply an intensity-based nonrigid registration algorithm to MRI-guided prostate brachytherapy clinical data and to assess its accuracy. Materials and Methods: A nonrigid registration of preoperative MRI to intraoperative MRI images was carried out in 16 cases using a Basis-Spline algorithm in a retrospective manner. The registration was assessed qualitatively by experts' visual inspection and quantitatively by measuring the Dice similarity coefficient (DSC) for total gland (TG), central gland (CG), and peripheral zone (PZ), the mutual information (MI) metric, and the fiducial registration error (FRE) between corresponding anatomical landmarks for both the nonrigid and a rigid registration method. Results: All 16 cases were successfully registered in less than 5 min. After the nonrigid registration, DSC values for TG, CG, PZ were 0.91, 0.89, 0.79, respectively, the MI metric was -0.19 ± 0.07 and FRE presented a value of 2.3 ± 1.8 mm. All the metrics were significantly better than in the case of rigid registration, as determined by one-sided t-tests. Conclusion: The intensity-based nonrigid registration method using clinical data was demonstrated to be feasible and showed statistically improved metrics when compare to only rigid registration. The method is a valuable tool to integrate pre- and intraoperative images for brachytherapy.

Original languageEnglish
Pages (from-to)1052-1058
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number5
DOIs
Publication statusPublished - 2009 Nov

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Brachytherapy
Prostate

Keywords

  • B-spline
  • Prostate brachytherapy
  • Signal intensity-based nonrigid registration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MRI signal intensity based B-spline nonrigid registration for pre- and intraoperative imaging during prostate brachytherapy. / Oguro, Sota; Tokuda, Junichi; Elhawary, Haytham; Haker, Steven; Kikinis, Ron; Tempany, Clare M C; Hata, Nobuhiko.

In: Journal of Magnetic Resonance Imaging, Vol. 30, No. 5, 11.2009, p. 1052-1058.

Research output: Contribution to journalArticle

Oguro, Sota ; Tokuda, Junichi ; Elhawary, Haytham ; Haker, Steven ; Kikinis, Ron ; Tempany, Clare M C ; Hata, Nobuhiko. / MRI signal intensity based B-spline nonrigid registration for pre- and intraoperative imaging during prostate brachytherapy. In: Journal of Magnetic Resonance Imaging. 2009 ; Vol. 30, No. 5. pp. 1052-1058.
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