Mucin-producing adenocarcinoma of the lung: Thin-section computed tomography findings in 48 patients and their effect on prognosis

Ukihide Tateishi, Nestor L. Müller, Takeshi Johkoh, Arafumi Maeshima, Hisao Asamura, Mitsuo Satake, Masahiko Kusumoto, Yasuaki Arai

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Abstract

Objective: To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung. Methods: The study included 48 patients with pathologically proven MPA who had thin-section CT before treatment. The CT findings were correlated with the histopathologic findings and with disease-free survival on follow-up in all patients. Results: Computed tomography findings identified in patients with MPA of the lung included an air bronchogram (n = 37, 77.1%), areas of ground-glass attenuation (n = 36, 75.0%), areas of air-space consolidation (n = 36, 75.0%), interlobular septal thickening (n = 33, 68.8%), bubble-like lucencies (n = 23, 47.9%), centrilobular nodules (n = 22, 45.8%), and mucus filling of airways (n = 19, 39.6%). Twenty-two (45.8%) of the 48 patients had intrapulmonary metastases. Centrilobular nodules (odds ratio [OR] = 6.7, 95% confidence interval: 1.1-41.4; P < 0.05) and mucus filling of airways (OR = 14.4, 95% 95% confidence interval: 2.0-102.7; P < 0.01) on thin-section CT were independently associated with an increased likelihood of intrapulmonary metastases. The 5-year disease-free survival rates were 67.9% and 38.4% for patients without and with intrapulmonary metastases, respectively (P < 0.05). The presence of centrilobular nodules (relative risk = 10.5, 95% confidence interval: 1.8-59.3; P < 0.01) on thin-section CT was an independent predictor of poor prognosis. Conclusion: Centrilobular nodules on CT are associated with a higher prevalence of intrapulmonary metastases and a poor prognosis in patients with MPA of the lung.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Computer Assisted Tomography
Volume29
Issue number3
DOIs
Publication statusPublished - 2005 May 1

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Keywords

  • Adenocarcinoma
  • Computed tomography
  • Lung
  • Mucin-producing tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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