Mucin-producing adenocarcinoma of the lung

Thin-section computed tomography findings in 48 patients and their effect on prognosis

Ukihide Tateishi, Nestor L. Müller, Takeshi Johkoh, Arafumi Maeshima, Hisao Asamura, Mitsuo Satake, Masahiko Kusumoto, Yasuaki Arai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung. Methods: The study included 48 patients with pathologically proven MPA who had thin-section CT before treatment. The CT findings were correlated with the histopathologic findings and with disease-free survival on follow-up in all patients. Results: Computed tomography findings identified in patients with MPA of the lung included an air bronchogram (n = 37, 77.1%), areas of ground-glass attenuation (n = 36, 75.0%), areas of air-space consolidation (n = 36, 75.0%), interlobular septal thickening (n = 33, 68.8%), bubble-like lucencies (n = 23, 47.9%), centrilobular nodules (n = 22, 45.8%), and mucus filling of airways (n = 19, 39.6%). Twenty-two (45.8%) of the 48 patients had intrapulmonary metastases. Centrilobular nodules (odds ratio [OR] = 6.7, 95% confidence interval: 1.1-41.4; P < 0.05) and mucus filling of airways (OR = 14.4, 95% 95% confidence interval: 2.0-102.7; P < 0.01) on thin-section CT were independently associated with an increased likelihood of intrapulmonary metastases. The 5-year disease-free survival rates were 67.9% and 38.4% for patients without and with intrapulmonary metastases, respectively (P < 0.05). The presence of centrilobular nodules (relative risk = 10.5, 95% confidence interval: 1.8-59.3; P < 0.01) on thin-section CT was an independent predictor of poor prognosis. Conclusion: Centrilobular nodules on CT are associated with a higher prevalence of intrapulmonary metastases and a poor prognosis in patients with MPA of the lung.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Computer Assisted Tomography
Volume29
Issue number3
DOIs
Publication statusPublished - 2005 May
Externally publishedYes

Fingerprint

Mucins
Tomography
Neoplasm Metastasis
Confidence Intervals
Mucus
Disease-Free Survival
Odds Ratio
Air
Adenocarcinoma of lung
Glass
Adenocarcinoma
Survival Rate

Keywords

  • Adenocarcinoma
  • Computed tomography
  • Lung
  • Mucin-producing tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Mucin-producing adenocarcinoma of the lung : Thin-section computed tomography findings in 48 patients and their effect on prognosis. / Tateishi, Ukihide; Müller, Nestor L.; Johkoh, Takeshi; Maeshima, Arafumi; Asamura, Hisao; Satake, Mitsuo; Kusumoto, Masahiko; Arai, Yasuaki.

In: Journal of Computer Assisted Tomography, Vol. 29, No. 3, 05.2005, p. 361-368.

Research output: Contribution to journalArticle

Tateishi, Ukihide ; Müller, Nestor L. ; Johkoh, Takeshi ; Maeshima, Arafumi ; Asamura, Hisao ; Satake, Mitsuo ; Kusumoto, Masahiko ; Arai, Yasuaki. / Mucin-producing adenocarcinoma of the lung : Thin-section computed tomography findings in 48 patients and their effect on prognosis. In: Journal of Computer Assisted Tomography. 2005 ; Vol. 29, No. 3. pp. 361-368.
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abstract = "Objective: To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung. Methods: The study included 48 patients with pathologically proven MPA who had thin-section CT before treatment. The CT findings were correlated with the histopathologic findings and with disease-free survival on follow-up in all patients. Results: Computed tomography findings identified in patients with MPA of the lung included an air bronchogram (n = 37, 77.1{\%}), areas of ground-glass attenuation (n = 36, 75.0{\%}), areas of air-space consolidation (n = 36, 75.0{\%}), interlobular septal thickening (n = 33, 68.8{\%}), bubble-like lucencies (n = 23, 47.9{\%}), centrilobular nodules (n = 22, 45.8{\%}), and mucus filling of airways (n = 19, 39.6{\%}). Twenty-two (45.8{\%}) of the 48 patients had intrapulmonary metastases. Centrilobular nodules (odds ratio [OR] = 6.7, 95{\%} confidence interval: 1.1-41.4; P < 0.05) and mucus filling of airways (OR = 14.4, 95{\%} 95{\%} confidence interval: 2.0-102.7; P < 0.01) on thin-section CT were independently associated with an increased likelihood of intrapulmonary metastases. The 5-year disease-free survival rates were 67.9{\%} and 38.4{\%} for patients without and with intrapulmonary metastases, respectively (P < 0.05). The presence of centrilobular nodules (relative risk = 10.5, 95{\%} confidence interval: 1.8-59.3; P < 0.01) on thin-section CT was an independent predictor of poor prognosis. Conclusion: Centrilobular nodules on CT are associated with a higher prevalence of intrapulmonary metastases and a poor prognosis in patients with MPA of the lung.",
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T1 - Mucin-producing adenocarcinoma of the lung

T2 - Thin-section computed tomography findings in 48 patients and their effect on prognosis

AU - Tateishi, Ukihide

AU - Müller, Nestor L.

AU - Johkoh, Takeshi

AU - Maeshima, Arafumi

AU - Asamura, Hisao

AU - Satake, Mitsuo

AU - Kusumoto, Masahiko

AU - Arai, Yasuaki

PY - 2005/5

Y1 - 2005/5

N2 - Objective: To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung. Methods: The study included 48 patients with pathologically proven MPA who had thin-section CT before treatment. The CT findings were correlated with the histopathologic findings and with disease-free survival on follow-up in all patients. Results: Computed tomography findings identified in patients with MPA of the lung included an air bronchogram (n = 37, 77.1%), areas of ground-glass attenuation (n = 36, 75.0%), areas of air-space consolidation (n = 36, 75.0%), interlobular septal thickening (n = 33, 68.8%), bubble-like lucencies (n = 23, 47.9%), centrilobular nodules (n = 22, 45.8%), and mucus filling of airways (n = 19, 39.6%). Twenty-two (45.8%) of the 48 patients had intrapulmonary metastases. Centrilobular nodules (odds ratio [OR] = 6.7, 95% confidence interval: 1.1-41.4; P < 0.05) and mucus filling of airways (OR = 14.4, 95% 95% confidence interval: 2.0-102.7; P < 0.01) on thin-section CT were independently associated with an increased likelihood of intrapulmonary metastases. The 5-year disease-free survival rates were 67.9% and 38.4% for patients without and with intrapulmonary metastases, respectively (P < 0.05). The presence of centrilobular nodules (relative risk = 10.5, 95% confidence interval: 1.8-59.3; P < 0.01) on thin-section CT was an independent predictor of poor prognosis. Conclusion: Centrilobular nodules on CT are associated with a higher prevalence of intrapulmonary metastases and a poor prognosis in patients with MPA of the lung.

AB - Objective: To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung. Methods: The study included 48 patients with pathologically proven MPA who had thin-section CT before treatment. The CT findings were correlated with the histopathologic findings and with disease-free survival on follow-up in all patients. Results: Computed tomography findings identified in patients with MPA of the lung included an air bronchogram (n = 37, 77.1%), areas of ground-glass attenuation (n = 36, 75.0%), areas of air-space consolidation (n = 36, 75.0%), interlobular septal thickening (n = 33, 68.8%), bubble-like lucencies (n = 23, 47.9%), centrilobular nodules (n = 22, 45.8%), and mucus filling of airways (n = 19, 39.6%). Twenty-two (45.8%) of the 48 patients had intrapulmonary metastases. Centrilobular nodules (odds ratio [OR] = 6.7, 95% confidence interval: 1.1-41.4; P < 0.05) and mucus filling of airways (OR = 14.4, 95% 95% confidence interval: 2.0-102.7; P < 0.01) on thin-section CT were independently associated with an increased likelihood of intrapulmonary metastases. The 5-year disease-free survival rates were 67.9% and 38.4% for patients without and with intrapulmonary metastases, respectively (P < 0.05). The presence of centrilobular nodules (relative risk = 10.5, 95% confidence interval: 1.8-59.3; P < 0.01) on thin-section CT was an independent predictor of poor prognosis. Conclusion: Centrilobular nodules on CT are associated with a higher prevalence of intrapulmonary metastases and a poor prognosis in patients with MPA of the lung.

KW - Adenocarcinoma

KW - Computed tomography

KW - Lung

KW - Mucin-producing tumor

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