Mucin-producing adenocarcinoma of the lung: Thin-section computed tomography findings in 48 patients and their effect on prognosis

Ukihide Tateishi, Nestor L. Müller, Takeshi Johkoh, Arafumi Maeshima, Hisao Asamura, Mitsuo Satake, Masahiko Kusumoto, Yasuaki Arai

Research output: Contribution to journalArticle

12 Citations (Scopus)


Objective: To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung. Methods: The study included 48 patients with pathologically proven MPA who had thin-section CT before treatment. The CT findings were correlated with the histopathologic findings and with disease-free survival on follow-up in all patients. Results: Computed tomography findings identified in patients with MPA of the lung included an air bronchogram (n = 37, 77.1%), areas of ground-glass attenuation (n = 36, 75.0%), areas of air-space consolidation (n = 36, 75.0%), interlobular septal thickening (n = 33, 68.8%), bubble-like lucencies (n = 23, 47.9%), centrilobular nodules (n = 22, 45.8%), and mucus filling of airways (n = 19, 39.6%). Twenty-two (45.8%) of the 48 patients had intrapulmonary metastases. Centrilobular nodules (odds ratio [OR] = 6.7, 95% confidence interval: 1.1-41.4; P < 0.05) and mucus filling of airways (OR = 14.4, 95% 95% confidence interval: 2.0-102.7; P < 0.01) on thin-section CT were independently associated with an increased likelihood of intrapulmonary metastases. The 5-year disease-free survival rates were 67.9% and 38.4% for patients without and with intrapulmonary metastases, respectively (P < 0.05). The presence of centrilobular nodules (relative risk = 10.5, 95% confidence interval: 1.8-59.3; P < 0.01) on thin-section CT was an independent predictor of poor prognosis. Conclusion: Centrilobular nodules on CT are associated with a higher prevalence of intrapulmonary metastases and a poor prognosis in patients with MPA of the lung.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Computer Assisted Tomography
Issue number3
Publication statusPublished - 2005 May 1



  • Adenocarcinoma
  • Computed tomography
  • Lung
  • Mucin-producing tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this