Mucin-producing tumors of the pancreas: Clinicopathological features, surgical treatment, and outcome

Mitsuhiro Inagaki, Masayuki Maguchi, Shuichi Kino, Mitsuhiro Obara, Akira Ishizaki, Kazuhiko Onodera, Kazunori Yokoyama, Isao Makino, Hidenori Ojima, Yoshihiko Tokusashi, Naoyuki Miyokawa, Shinichi Kasai

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Mucin-producing tumors (MPTs) of the pancreas are increasingly being recognized. To evaluate the appropriate surgical treatment and predict the prognosis of MPTs, we performed a retrospective clinicopathological study in 51 patients, 27 with benign tumors and 24 with borderline/malignant tumors. Three of the malignant tumors showed stromal invasion and lymph node metastasis on histological examination. Of the 24 patients with borderline/malignant tumors, 2 died of MPTs and 4 died of other diseases. At the last follow-up, 35 patients were alive and well. The 5-year postoperative survival rate was 90% for patients with benign tumors, and 78% of these with borderline/malignant tumors. Five of the patients with borderline/malignant tumors had multicentric tumors. Three of these patients underwent resection of the rest of the pancreas, 5, 6, and 8 years, respectively, after the first operation. Extended radical resection is required for malignant MPT with invasion of the pancreatic stroma. We prefer to perform pancreatogastrostomy or Imanaga's procedure to allow examination of the body and tail of the pancreas by endoscopic retrograde pancreatography after resection of the pancreatic head. Careful follow-up for a long period may be the most prudent approach for detecting multiple MPTs in the residual pancreas after surgical treatment.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume6
Issue number3
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Mucins
Pancreas
Neoplasms
Mucin-2
Residual Neoplasm
Survival Rate
Retrospective Studies
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Duodenum-preserving pancreas head resection
  • Mucin-producing tumor
  • Pancreas
  • Pylorus-preserving pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Inagaki, M., Maguchi, M., Kino, S., Obara, M., Ishizaki, A., Onodera, K., ... Kasai, S. (1999). Mucin-producing tumors of the pancreas: Clinicopathological features, surgical treatment, and outcome. Journal of Hepato-Biliary-Pancreatic Surgery, 6(3), 281-285.

Mucin-producing tumors of the pancreas : Clinicopathological features, surgical treatment, and outcome. / Inagaki, Mitsuhiro; Maguchi, Masayuki; Kino, Shuichi; Obara, Mitsuhiro; Ishizaki, Akira; Onodera, Kazuhiko; Yokoyama, Kazunori; Makino, Isao; Ojima, Hidenori; Tokusashi, Yoshihiko; Miyokawa, Naoyuki; Kasai, Shinichi.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 6, No. 3, 1999, p. 281-285.

Research output: Contribution to journalArticle

Inagaki, M, Maguchi, M, Kino, S, Obara, M, Ishizaki, A, Onodera, K, Yokoyama, K, Makino, I, Ojima, H, Tokusashi, Y, Miyokawa, N & Kasai, S 1999, 'Mucin-producing tumors of the pancreas: Clinicopathological features, surgical treatment, and outcome', Journal of Hepato-Biliary-Pancreatic Surgery, vol. 6, no. 3, pp. 281-285.
Inagaki, Mitsuhiro ; Maguchi, Masayuki ; Kino, Shuichi ; Obara, Mitsuhiro ; Ishizaki, Akira ; Onodera, Kazuhiko ; Yokoyama, Kazunori ; Makino, Isao ; Ojima, Hidenori ; Tokusashi, Yoshihiko ; Miyokawa, Naoyuki ; Kasai, Shinichi. / Mucin-producing tumors of the pancreas : Clinicopathological features, surgical treatment, and outcome. In: Journal of Hepato-Biliary-Pancreatic Surgery. 1999 ; Vol. 6, No. 3. pp. 281-285.
@article{783ad17a00154f7ba74df6e420072b31,
title = "Mucin-producing tumors of the pancreas: Clinicopathological features, surgical treatment, and outcome",
abstract = "Mucin-producing tumors (MPTs) of the pancreas are increasingly being recognized. To evaluate the appropriate surgical treatment and predict the prognosis of MPTs, we performed a retrospective clinicopathological study in 51 patients, 27 with benign tumors and 24 with borderline/malignant tumors. Three of the malignant tumors showed stromal invasion and lymph node metastasis on histological examination. Of the 24 patients with borderline/malignant tumors, 2 died of MPTs and 4 died of other diseases. At the last follow-up, 35 patients were alive and well. The 5-year postoperative survival rate was 90{\%} for patients with benign tumors, and 78{\%} of these with borderline/malignant tumors. Five of the patients with borderline/malignant tumors had multicentric tumors. Three of these patients underwent resection of the rest of the pancreas, 5, 6, and 8 years, respectively, after the first operation. Extended radical resection is required for malignant MPT with invasion of the pancreatic stroma. We prefer to perform pancreatogastrostomy or Imanaga's procedure to allow examination of the body and tail of the pancreas by endoscopic retrograde pancreatography after resection of the pancreatic head. Careful follow-up for a long period may be the most prudent approach for detecting multiple MPTs in the residual pancreas after surgical treatment.",
keywords = "Duodenum-preserving pancreas head resection, Mucin-producing tumor, Pancreas, Pylorus-preserving pancreaticoduodenectomy",
author = "Mitsuhiro Inagaki and Masayuki Maguchi and Shuichi Kino and Mitsuhiro Obara and Akira Ishizaki and Kazuhiko Onodera and Kazunori Yokoyama and Isao Makino and Hidenori Ojima and Yoshihiko Tokusashi and Naoyuki Miyokawa and Shinichi Kasai",
year = "1999",
language = "English",
volume = "6",
pages = "281--285",
journal = "Journal of Hepato-Biliary-Pancreatic Sciences",
issn = "1868-6974",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Mucin-producing tumors of the pancreas

T2 - Clinicopathological features, surgical treatment, and outcome

AU - Inagaki, Mitsuhiro

AU - Maguchi, Masayuki

AU - Kino, Shuichi

AU - Obara, Mitsuhiro

AU - Ishizaki, Akira

AU - Onodera, Kazuhiko

AU - Yokoyama, Kazunori

AU - Makino, Isao

AU - Ojima, Hidenori

AU - Tokusashi, Yoshihiko

AU - Miyokawa, Naoyuki

AU - Kasai, Shinichi

PY - 1999

Y1 - 1999

N2 - Mucin-producing tumors (MPTs) of the pancreas are increasingly being recognized. To evaluate the appropriate surgical treatment and predict the prognosis of MPTs, we performed a retrospective clinicopathological study in 51 patients, 27 with benign tumors and 24 with borderline/malignant tumors. Three of the malignant tumors showed stromal invasion and lymph node metastasis on histological examination. Of the 24 patients with borderline/malignant tumors, 2 died of MPTs and 4 died of other diseases. At the last follow-up, 35 patients were alive and well. The 5-year postoperative survival rate was 90% for patients with benign tumors, and 78% of these with borderline/malignant tumors. Five of the patients with borderline/malignant tumors had multicentric tumors. Three of these patients underwent resection of the rest of the pancreas, 5, 6, and 8 years, respectively, after the first operation. Extended radical resection is required for malignant MPT with invasion of the pancreatic stroma. We prefer to perform pancreatogastrostomy or Imanaga's procedure to allow examination of the body and tail of the pancreas by endoscopic retrograde pancreatography after resection of the pancreatic head. Careful follow-up for a long period may be the most prudent approach for detecting multiple MPTs in the residual pancreas after surgical treatment.

AB - Mucin-producing tumors (MPTs) of the pancreas are increasingly being recognized. To evaluate the appropriate surgical treatment and predict the prognosis of MPTs, we performed a retrospective clinicopathological study in 51 patients, 27 with benign tumors and 24 with borderline/malignant tumors. Three of the malignant tumors showed stromal invasion and lymph node metastasis on histological examination. Of the 24 patients with borderline/malignant tumors, 2 died of MPTs and 4 died of other diseases. At the last follow-up, 35 patients were alive and well. The 5-year postoperative survival rate was 90% for patients with benign tumors, and 78% of these with borderline/malignant tumors. Five of the patients with borderline/malignant tumors had multicentric tumors. Three of these patients underwent resection of the rest of the pancreas, 5, 6, and 8 years, respectively, after the first operation. Extended radical resection is required for malignant MPT with invasion of the pancreatic stroma. We prefer to perform pancreatogastrostomy or Imanaga's procedure to allow examination of the body and tail of the pancreas by endoscopic retrograde pancreatography after resection of the pancreatic head. Careful follow-up for a long period may be the most prudent approach for detecting multiple MPTs in the residual pancreas after surgical treatment.

KW - Duodenum-preserving pancreas head resection

KW - Mucin-producing tumor

KW - Pancreas

KW - Pylorus-preserving pancreaticoduodenectomy

UR - http://www.scopus.com/inward/record.url?scp=0033286366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033286366&partnerID=8YFLogxK

M3 - Article

C2 - 10526064

AN - SCOPUS:0033286366

VL - 6

SP - 281

EP - 285

JO - Journal of Hepato-Biliary-Pancreatic Sciences

JF - Journal of Hepato-Biliary-Pancreatic Sciences

SN - 1868-6974

IS - 3

ER -