Mucinous breast carcinoma with a lobular neoplasia component: A subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation

Kenjiro Jimbo, Hitoshi Tsuda, Masayuki Yoshida, Akiko Miyagi-Maeshima, Yuka Sasaki-Katsurada, Sota Asaga, Takashi Hojo, Yuukou Kitagawa, Takayuki Kinoshita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated whether some mucinous carcinomas (MUCs) are associated with lobular neoplasia (LN) components, and if so, whether this subset has any distinct biological properties. MUC specimens from 41 patients were stratified into pure and mixed types. The LN components adjacent to MUC lesions were examined histopathologically. We also tested immunohistochemically for E-cadherin, β-catenin, and the neuroendocrine markers chromogranin A and synaptophysin; and compared results between MUCs with and without LN. Of 41 patients with MUC, LN was detected in 12 patients (29%); LN alone was the noninvasive component in 8 patients (20%). Decreased E-cadherin and β-catenin expression in the MUC component was detected in 2 (17%) and 7 (58%) cases, respectively, of MUC with LN, compared with 0% (P = 0.080) and 21% (P = 0.018) in MUCs without LN. Neuroendocrine factors were frequently detected in MUCs with LN (42%) and without LN (52%), but tended to be less frequent in MUCs with only LN components (25%) than in other MUCs (55%; P = 0.133). MUCs associated with LN components appear to be a biologically characteristic subset that frequently shows decreased cell-cell adhesion, cell polarity molecules and lack of neuroendocrine differentiation.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalPathology International
Volume64
Issue number5
DOIs
Publication statusPublished - 2014

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Mucinous Adenocarcinoma
Cell Polarity
Cell Adhesion Molecules
Breast Neoplasms
Neoplasms
Catenins
Cadherins
Chromogranin A
Synaptophysin
Cell Adhesion

Keywords

  • Breast
  • E-cadherin
  • Lobular neoplasia
  • Mucinous carcinoma
  • Neuroendocrine differentiation
  • β-catenin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Mucinous breast carcinoma with a lobular neoplasia component : A subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation. / Jimbo, Kenjiro; Tsuda, Hitoshi; Yoshida, Masayuki; Miyagi-Maeshima, Akiko; Sasaki-Katsurada, Yuka; Asaga, Sota; Hojo, Takashi; Kitagawa, Yuukou; Kinoshita, Takayuki.

In: Pathology International, Vol. 64, No. 5, 2014, p. 217-223.

Research output: Contribution to journalArticle

Jimbo, Kenjiro ; Tsuda, Hitoshi ; Yoshida, Masayuki ; Miyagi-Maeshima, Akiko ; Sasaki-Katsurada, Yuka ; Asaga, Sota ; Hojo, Takashi ; Kitagawa, Yuukou ; Kinoshita, Takayuki. / Mucinous breast carcinoma with a lobular neoplasia component : A subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation. In: Pathology International. 2014 ; Vol. 64, No. 5. pp. 217-223.
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