Mucinous micropapillary pattern in lung adenocarcinomas: A unique histology with genetic correlates

Tsugumasa Kamata, Akihiko Yoshida, Kouya Shiraishi, Koh Furuta, Tomoo Kosuge, Shun Ichi Watanabe, Hisao Asamura, Koji Tsuta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims: In lung adenocarcinoma (ADC), micropapillary carcinomas (MPCs) are associated with poor prognosis because these tumours exhibit higher metastatic potential. Despite this, there are no studies investigating the differences between mucinous and non-mucinous MPC. Methods and results: We evaluated the proportion of micropapillary components in lung ADCs, and compared the differences with respect to the presence or absence of associated mucin. Tumour specimens from 694 patients with consecutively resected primary lung ADC were reviewed, and 37 cases of invasive mucinous ADCs were excluded. A significant (≥5%) micropapillary component was noted in 320 (48.7%) of 657 evaluable cases. When the cases with micropapillary component were divided into 67 (20.9%) mucinous and 253 (79.1%) non-mucinous subtypes, tumours with mucinous micropapillary component exhibited significantly more aggressive pathological features, a higher proportion of HER2 mutations (P = 0.002) and ALK rearrangements (P <0.001), and a lower proportion of EGFR mutations (P = 0.038) compared to those with a non-mucinous micropapillary component. In survival analyses, mucinous MPC tended to be more aggressive compared with non-mucinous MPC, but its prognostic value was not statistically significant (P = 0.076). Conclusions: Mucinous micropapillary pattern is an under-recognized unique growth associated significantly with HER2 mutation and ALK rearrangement.

Original languageEnglish
Pages (from-to)356-366
Number of pages11
JournalHistopathology
Volume68
Issue number3
DOIs
Publication statusPublished - 2016 Feb 1

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Histology
Carcinoma
Mutation
Mucinous Adenocarcinoma
Neoplasms
Mucins
Survival Analysis
Lung
Growth
Adenocarcinoma of lung

Keywords

  • Human epidermal growth factor receptor 2 mutation
  • Lung adenocarcinoma
  • Micropapillary
  • Mucinous

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Kamata, T., Yoshida, A., Shiraishi, K., Furuta, K., Kosuge, T., Watanabe, S. I., ... Tsuta, K. (2016). Mucinous micropapillary pattern in lung adenocarcinomas: A unique histology with genetic correlates. Histopathology, 68(3), 356-366. https://doi.org/10.1111/his.12763

Mucinous micropapillary pattern in lung adenocarcinomas : A unique histology with genetic correlates. / Kamata, Tsugumasa; Yoshida, Akihiko; Shiraishi, Kouya; Furuta, Koh; Kosuge, Tomoo; Watanabe, Shun Ichi; Asamura, Hisao; Tsuta, Koji.

In: Histopathology, Vol. 68, No. 3, 01.02.2016, p. 356-366.

Research output: Contribution to journalArticle

Kamata, T, Yoshida, A, Shiraishi, K, Furuta, K, Kosuge, T, Watanabe, SI, Asamura, H & Tsuta, K 2016, 'Mucinous micropapillary pattern in lung adenocarcinomas: A unique histology with genetic correlates', Histopathology, vol. 68, no. 3, pp. 356-366. https://doi.org/10.1111/his.12763
Kamata T, Yoshida A, Shiraishi K, Furuta K, Kosuge T, Watanabe SI et al. Mucinous micropapillary pattern in lung adenocarcinomas: A unique histology with genetic correlates. Histopathology. 2016 Feb 1;68(3):356-366. https://doi.org/10.1111/his.12763
Kamata, Tsugumasa ; Yoshida, Akihiko ; Shiraishi, Kouya ; Furuta, Koh ; Kosuge, Tomoo ; Watanabe, Shun Ichi ; Asamura, Hisao ; Tsuta, Koji. / Mucinous micropapillary pattern in lung adenocarcinomas : A unique histology with genetic correlates. In: Histopathology. 2016 ; Vol. 68, No. 3. pp. 356-366.
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