Abstract
Mullerian inhibiting substance (MIS) is a gonadal hormone synthesized by Sertoli cells of the testis and granulosa cells of the ovary. To facilitate the use of MIS for the evaluation of intersex disorders and as a tumor marker in women with MIS-expressing ovarian tumors, we measured MIS in 600 serum samples from males and females. These data show that mean MIS values for males rise rapidly during the first year of life and are highest during late infancy, then gradually decline until puberty. In contrast, MIS values in females are lowest at birth and exhibit a minimal increase throughout the prepubertal years. Whereas MIS is uniformly measurable in all prepubertal boys studied, it is undetectable in most prepubertal female subjects. These data reveal an easily discernible sexually dimorphic pattern of expression and confirm that MIS can be used as a testis-specific marker during infancy and early childhood. MIS values that are above the upper limits for females are discriminatory for the presence of testicular tissue or ovarian tumor, and those below the lower limits for males are consistent with dysgenetic or absent testes or the presence of ovarian tissue. These data will enable normal and abnormal levels of MIS to be differentiated with higher precision and will facilitate the use of MIS in the management of gonadal disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 571-576 |
| Number of pages | 6 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 81 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Mullerian inhibiting substance in humans : Normal levels from infancy to adulthood. / Lee, Mary M.; Donahoe, Patricia K.; Hasegawa, Tomonobu; Silverman, Bernard; Crist, Gretchen B.; Best, Sharon; Hasegawa, Yukihiro; Noto, Richard A.; Schoenfeld, David; MacLaughlin, David T.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 81, No. 2, 1996, p. 571-576.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mullerian inhibiting substance in humans
T2 - Normal levels from infancy to adulthood
AU - Lee, Mary M.
AU - Donahoe, Patricia K.
AU - Hasegawa, Tomonobu
AU - Silverman, Bernard
AU - Crist, Gretchen B.
AU - Best, Sharon
AU - Hasegawa, Yukihiro
AU - Noto, Richard A.
AU - Schoenfeld, David
AU - MacLaughlin, David T.
PY - 1996
Y1 - 1996
N2 - Mullerian inhibiting substance (MIS) is a gonadal hormone synthesized by Sertoli cells of the testis and granulosa cells of the ovary. To facilitate the use of MIS for the evaluation of intersex disorders and as a tumor marker in women with MIS-expressing ovarian tumors, we measured MIS in 600 serum samples from males and females. These data show that mean MIS values for males rise rapidly during the first year of life and are highest during late infancy, then gradually decline until puberty. In contrast, MIS values in females are lowest at birth and exhibit a minimal increase throughout the prepubertal years. Whereas MIS is uniformly measurable in all prepubertal boys studied, it is undetectable in most prepubertal female subjects. These data reveal an easily discernible sexually dimorphic pattern of expression and confirm that MIS can be used as a testis-specific marker during infancy and early childhood. MIS values that are above the upper limits for females are discriminatory for the presence of testicular tissue or ovarian tumor, and those below the lower limits for males are consistent with dysgenetic or absent testes or the presence of ovarian tissue. These data will enable normal and abnormal levels of MIS to be differentiated with higher precision and will facilitate the use of MIS in the management of gonadal disorders.
AB - Mullerian inhibiting substance (MIS) is a gonadal hormone synthesized by Sertoli cells of the testis and granulosa cells of the ovary. To facilitate the use of MIS for the evaluation of intersex disorders and as a tumor marker in women with MIS-expressing ovarian tumors, we measured MIS in 600 serum samples from males and females. These data show that mean MIS values for males rise rapidly during the first year of life and are highest during late infancy, then gradually decline until puberty. In contrast, MIS values in females are lowest at birth and exhibit a minimal increase throughout the prepubertal years. Whereas MIS is uniformly measurable in all prepubertal boys studied, it is undetectable in most prepubertal female subjects. These data reveal an easily discernible sexually dimorphic pattern of expression and confirm that MIS can be used as a testis-specific marker during infancy and early childhood. MIS values that are above the upper limits for females are discriminatory for the presence of testicular tissue or ovarian tumor, and those below the lower limits for males are consistent with dysgenetic or absent testes or the presence of ovarian tissue. These data will enable normal and abnormal levels of MIS to be differentiated with higher precision and will facilitate the use of MIS in the management of gonadal disorders.
UR - http://www.scopus.com/inward/record.url?scp=9044238435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9044238435&partnerID=8YFLogxK
U2 - 10.1210/jc.81.2.571
DO - 10.1210/jc.81.2.571
M3 - Article
C2 - 8636269
AN - SCOPUS:9044238435
VL - 81
SP - 571
EP - 576
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -