TY - JOUR
T1 - Mult-component analysis of urine of dogs with liver diseases by high-performance liquid chromatography
AU - Abe, Yoshiko
AU - Kobayashi, Eriko
AU - Suzuki, Noriko
AU - Kaneko, Akiko
AU - Fujie, Tadao
AU - Nagata, Yoshiko
AU - Matsushima, Yoshikazu
AU - Takai, Nobuharu
AU - Watanabe, Toshifumi
AU - Otsubo, Osamu
PY - 1987
Y1 - 1987
N2 - Components of the urine of normal dogs and dogs with liver diseases were analysed by high-performance liquid chromatography (HPLC) using a macroreticular anion-exchange resin with UV detection. The dogs with liver diseases were experimentally prepared by either Eck fistula by portal-caval anastomosis, dimethylnitrosamine-induced liver failure or total hepatectomy by operation. Eighteen chromatographic peaks were numbered and the cross-correlation coefficient of the intensities of every pair of peaks was computed. There were high correlations between several pairs of peaks according to the types and degrees of the hepatic failures, whereas no significant correlation was observed for the peak pairs of normal urine samples. The results showed that HPLC analysis of urine is useful in the diagnosis of the physiological state in liver dysfunction.
AB - Components of the urine of normal dogs and dogs with liver diseases were analysed by high-performance liquid chromatography (HPLC) using a macroreticular anion-exchange resin with UV detection. The dogs with liver diseases were experimentally prepared by either Eck fistula by portal-caval anastomosis, dimethylnitrosamine-induced liver failure or total hepatectomy by operation. Eighteen chromatographic peaks were numbered and the cross-correlation coefficient of the intensities of every pair of peaks was computed. There were high correlations between several pairs of peaks according to the types and degrees of the hepatic failures, whereas no significant correlation was observed for the peak pairs of normal urine samples. The results showed that HPLC analysis of urine is useful in the diagnosis of the physiological state in liver dysfunction.
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U2 - 10.1016/S0021-9673(01)94579-0
DO - 10.1016/S0021-9673(01)94579-0
M3 - Article
C2 - 3558599
AN - SCOPUS:0023160429
SN - 0021-9673
VL - 386
SP - 11
EP - 17
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - C
ER -