Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice

Huijuan Jia; Wanping Aw; Manaka Hanate; Shoko Takahashi; Kenji Saito; Hiroshi Tanaka; Masaru Tomita; Hisanori Kato

doi:10.1016/j.jff.2014.09.018

Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice

Huijuan Jia, Wanping Aw, Manaka Hanate, Shoko Takahashi, Kenji Saito, Hiroshi Tanaka, Masaru Tomita, Hisanori Kato

Faculty of Environment and Information Studies

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Here we describe our unprecedented approach in proposing parsley as a nutraceutical intervention in inflammatory bowel disease (IBD) via multi-omics evaluation using dextran sodium sulphate (DSS)-induced colitis. Seven-week-old male C57BL/6J mice were fed either 2% parsley or basal diet and drank normal-drinking-water for 1 week after which colitis was induced by administering 1.5% (w/v) DSS-drinking-water for 9 days. Parsley supplementation significantly improved colon shortening and increased disease activity index. Colonic transcriptome revealed down-regulation of inflammatory cytokines, hepatic transcriptome and metabolome revealed up-regulation of fatty-acid synthesis genes, thereby improving body weight loss. Down-regulated cancer markers were observed in the hepatic transcriptome and proteome. Plasma metabolite analysis indicated shifts in the citric and urea cycle, implicating improved impaired glycolysis and oxidative stress. Parsley's role in preventing against IBD was highlighted by this pioneering multi-integrated-omics which is expected to be useful and informative, and shape the future of nutraceutical and functional food research.

Original language	English
Pages (from-to)	438-448
Number of pages	11
Journal	Journal of Functional Foods
Volume	11
Issue number	C
DOIs	https://doi.org/10.1016/j.jff.2014.09.018
Publication status	Published - 2014

Keywords

Inflammatory bowel disease
Metabolome
Parsley supplementation
Proteome
Transcriptome

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jff.2014.09.018

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title = "Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice",

abstract = "Here we describe our unprecedented approach in proposing parsley as a nutraceutical intervention in inflammatory bowel disease (IBD) via multi-omics evaluation using dextran sodium sulphate (DSS)-induced colitis. Seven-week-old male C57BL/6J mice were fed either 2% parsley or basal diet and drank normal-drinking-water for 1 week after which colitis was induced by administering 1.5% (w/v) DSS-drinking-water for 9 days. Parsley supplementation significantly improved colon shortening and increased disease activity index. Colonic transcriptome revealed down-regulation of inflammatory cytokines, hepatic transcriptome and metabolome revealed up-regulation of fatty-acid synthesis genes, thereby improving body weight loss. Down-regulated cancer markers were observed in the hepatic transcriptome and proteome. Plasma metabolite analysis indicated shifts in the citric and urea cycle, implicating improved impaired glycolysis and oxidative stress. Parsley's role in preventing against IBD was highlighted by this pioneering multi-integrated-omics which is expected to be useful and informative, and shape the future of nutraceutical and functional food research.",

keywords = "Inflammatory bowel disease, Metabolome, Parsley supplementation, Proteome, Transcriptome",

author = "Huijuan Jia and Wanping Aw and Manaka Hanate and Shoko Takahashi and Kenji Saito and Hiroshi Tanaka and Masaru Tomita and Hisanori Kato",

note = "Funding Information: This study was supported in part by a grant-in-aid for JSPS Postdoctoral Fellowship for Foreign Researchers Fellows from the Japan Society for the Promotion of Science . We would like to thank Professor Masatoshi Hori, Graduate School of Agricultural and Life Sciences, The University of Tokyo, who gave us valuable advice. We also sincerely thank Human Metabolome Technologies for supporting the part of metabolome analysis. H.J. and W.A. designed the research; H.J., W.A. and M.H. conducted the experiments; H.J., W.A., S.T., and H.T. analyzed the data; K.S. and M.T. performed the statistical analysis; and H.J. and W.A. wrote the paper. H. K. had primary responsibility for the final content. All authors read and approved the final manuscript. Publisher Copyright: {\textcopyright} 2014 The Authors.",

year = "2014",

doi = "10.1016/j.jff.2014.09.018",

language = "English",

volume = "11",

pages = "438--448",

journal = "Journal of Functional Foods",

issn = "1756-4646",

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T1 - Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice

AU - Jia, Huijuan

AU - Aw, Wanping

AU - Hanate, Manaka

AU - Takahashi, Shoko

AU - Saito, Kenji

AU - Tanaka, Hiroshi

AU - Tomita, Masaru

AU - Kato, Hisanori

N1 - Funding Information: This study was supported in part by a grant-in-aid for JSPS Postdoctoral Fellowship for Foreign Researchers Fellows from the Japan Society for the Promotion of Science . We would like to thank Professor Masatoshi Hori, Graduate School of Agricultural and Life Sciences, The University of Tokyo, who gave us valuable advice. We also sincerely thank Human Metabolome Technologies for supporting the part of metabolome analysis. H.J. and W.A. designed the research; H.J., W.A. and M.H. conducted the experiments; H.J., W.A., S.T., and H.T. analyzed the data; K.S. and M.T. performed the statistical analysis; and H.J. and W.A. wrote the paper. H. K. had primary responsibility for the final content. All authors read and approved the final manuscript. Publisher Copyright: © 2014 The Authors.

PY - 2014

Y1 - 2014

N2 - Here we describe our unprecedented approach in proposing parsley as a nutraceutical intervention in inflammatory bowel disease (IBD) via multi-omics evaluation using dextran sodium sulphate (DSS)-induced colitis. Seven-week-old male C57BL/6J mice were fed either 2% parsley or basal diet and drank normal-drinking-water for 1 week after which colitis was induced by administering 1.5% (w/v) DSS-drinking-water for 9 days. Parsley supplementation significantly improved colon shortening and increased disease activity index. Colonic transcriptome revealed down-regulation of inflammatory cytokines, hepatic transcriptome and metabolome revealed up-regulation of fatty-acid synthesis genes, thereby improving body weight loss. Down-regulated cancer markers were observed in the hepatic transcriptome and proteome. Plasma metabolite analysis indicated shifts in the citric and urea cycle, implicating improved impaired glycolysis and oxidative stress. Parsley's role in preventing against IBD was highlighted by this pioneering multi-integrated-omics which is expected to be useful and informative, and shape the future of nutraceutical and functional food research.

AB - Here we describe our unprecedented approach in proposing parsley as a nutraceutical intervention in inflammatory bowel disease (IBD) via multi-omics evaluation using dextran sodium sulphate (DSS)-induced colitis. Seven-week-old male C57BL/6J mice were fed either 2% parsley or basal diet and drank normal-drinking-water for 1 week after which colitis was induced by administering 1.5% (w/v) DSS-drinking-water for 9 days. Parsley supplementation significantly improved colon shortening and increased disease activity index. Colonic transcriptome revealed down-regulation of inflammatory cytokines, hepatic transcriptome and metabolome revealed up-regulation of fatty-acid synthesis genes, thereby improving body weight loss. Down-regulated cancer markers were observed in the hepatic transcriptome and proteome. Plasma metabolite analysis indicated shifts in the citric and urea cycle, implicating improved impaired glycolysis and oxidative stress. Parsley's role in preventing against IBD was highlighted by this pioneering multi-integrated-omics which is expected to be useful and informative, and shape the future of nutraceutical and functional food research.

KW - Inflammatory bowel disease

KW - Metabolome

KW - Parsley supplementation

KW - Proteome

KW - Transcriptome

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U2 - 10.1016/j.jff.2014.09.018

DO - 10.1016/j.jff.2014.09.018

M3 - Article

AN - SCOPUS:84926395853

SN - 1756-4646

VL - 11

SP - 438

EP - 448

JO - Journal of Functional Foods

JF - Journal of Functional Foods

IS - C

ER -

Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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