Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice

Huijuan Jia, Wanping Aw, Manaka Hanate, Shoko Takahashi, Kenji Saito, Hiroshi Tanaka, Masaru Tomita, Hisanori Kato

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Here we describe our unprecedented approach in proposing parsley as a nutraceutical intervention in inflammatory bowel disease (IBD) via multi-omics evaluation using dextran sodium sulphate (DSS)-induced colitis. Seven-week-old male C57BL/6J mice were fed either 2% parsley or basal diet and drank normal-drinking-water for 1 week after which colitis was induced by administering 1.5% (w/v) DSS-drinking-water for 9 days. Parsley supplementation significantly improved colon shortening and increased disease activity index. Colonic transcriptome revealed down-regulation of inflammatory cytokines, hepatic transcriptome and metabolome revealed up-regulation of fatty-acid synthesis genes, thereby improving body weight loss. Down-regulated cancer markers were observed in the hepatic transcriptome and proteome. Plasma metabolite analysis indicated shifts in the citric and urea cycle, implicating improved impaired glycolysis and oxidative stress. Parsley's role in preventing against IBD was highlighted by this pioneering multi-integrated-omics which is expected to be useful and informative, and shape the future of nutraceutical and functional food research.

Original languageEnglish
Pages (from-to)438-448
Number of pages11
JournalJournal of Functional Foods
Volume11
Issue numberC
DOIs
Publication statusPublished - 2014

Fingerprint

Petroselinum
Petroselinum crispum
Dextran Sulfate
parsley
sodium sulfate
dextran
Transcriptome
transcriptome
functional foods
inflammatory bowel disease
colitis
mice
Colitis
Dietary Supplements
Inflammatory Bowel Diseases
Drinking Water
drinking water
metabolome
liver
Functional Food

Keywords

  • Inflammatory bowel disease
  • Metabolome
  • Parsley supplementation
  • Proteome
  • Transcriptome

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice. / Jia, Huijuan; Aw, Wanping; Hanate, Manaka; Takahashi, Shoko; Saito, Kenji; Tanaka, Hiroshi; Tomita, Masaru; Kato, Hisanori.

In: Journal of Functional Foods, Vol. 11, No. C, 2014, p. 438-448.

Research output: Contribution to journalArticle

Jia, Huijuan ; Aw, Wanping ; Hanate, Manaka ; Takahashi, Shoko ; Saito, Kenji ; Tanaka, Hiroshi ; Tomita, Masaru ; Kato, Hisanori. / Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice. In: Journal of Functional Foods. 2014 ; Vol. 11, No. C. pp. 438-448.
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