Multi-omics data-driven systems biology of E. coli

Nobuyoshi Ishii, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

The omics, which means comprehensive analysis of a specific layer in a cellular system, are emerging as essential methodological approaches for molecular biology and systems biology. However, single omics analysis does not always provide enough information to understand the behaviors of a cellular system. Therefore, a combination of multiple omics analyses, the multi-omics approach, is required to acquire a precise picture of living organisms. In this chapter, basic concepts of omics studies, and recent technologies in the omics of metabolism and published multi-omics analyses of Escherichia coli, are reviewed. Subsequently, a large-scale multi-omics analysis of E. coli K-12, including transcriptomics, proteomics, metabolomics and fluxomics, is presented. This study uncovered the complementary strategies of E. coli that result in a metabolic network robust against various types of perturbations, therefore demonstrating the power of a multi-omics, data-driven approach for understanding the functional principles of total cellular systems.

Original languageEnglish
Title of host publicationSystems Biology and Biotechnology of Escherichia coli
PublisherSpringer Netherlands
Pages41-57
Number of pages17
ISBN (Print)9781402093937
DOIs
Publication statusPublished - 2009

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Systems Biology
Information Systems
Escherichia coli
Metabolomics
Metabolic Networks and Pathways
Proteomics
Molecular Biology
Technology

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Ishii, N., & Tomita, M. (2009). Multi-omics data-driven systems biology of E. coli. In Systems Biology and Biotechnology of Escherichia coli (pp. 41-57). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9394-4_3

Multi-omics data-driven systems biology of E. coli. / Ishii, Nobuyoshi; Tomita, Masaru.

Systems Biology and Biotechnology of Escherichia coli. Springer Netherlands, 2009. p. 41-57.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ishii, N & Tomita, M 2009, Multi-omics data-driven systems biology of E. coli. in Systems Biology and Biotechnology of Escherichia coli. Springer Netherlands, pp. 41-57. https://doi.org/10.1007/978-1-4020-9394-4_3
Ishii N, Tomita M. Multi-omics data-driven systems biology of E. coli. In Systems Biology and Biotechnology of Escherichia coli. Springer Netherlands. 2009. p. 41-57 https://doi.org/10.1007/978-1-4020-9394-4_3
Ishii, Nobuyoshi ; Tomita, Masaru. / Multi-omics data-driven systems biology of E. coli. Systems Biology and Biotechnology of Escherichia coli. Springer Netherlands, 2009. pp. 41-57
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