Multicanonical algorithm combined with the RISM theory for simulating peptides in aqueous solution

Ayori Mitsutake, Masahiro Kinoshita, Yuko Okamoto, Fumio Hirata

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

This Letter contributes to the development of the first-principles prediction methods for peptide and protein conformations in aqueous solution. We report the results of the first attempt to combine the multicanonical algorithm for extensive sampling of the phase space and the reference interaction site model (RISM) theory for incorporating solvent effects. Met-enkephalin in aqueous solution is chosen as an example system. Averages of the energy functions, end-to-end distance, and dihedral-angle distributions are calculated as functions of temperature.

Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalChemical Physics Letters
Volume329
Issue number3-4
DOIs
Publication statusPublished - 2000 Oct 20

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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