Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern

Michiie Sakamoto, S. Hirohashi, H. Tsuda, Y. Shimosato, M. Makuuchi, Y. Hosoda

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.

Original languageEnglish
Pages (from-to)1064-1067
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume13
Issue number12
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Virus Integration
Hepatitis B virus
Hepatocellular Carcinoma
DNA
Hepatitis B Surface Antigens
Southern Blotting
Liver
Serum

Keywords

  • Hepatitis B virus DNA
  • Hepatocellular carcinoma
  • Liver
  • Multicentric development

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern. / Sakamoto, Michiie; Hirohashi, S.; Tsuda, H.; Shimosato, Y.; Makuuchi, M.; Hosoda, Y.

In: American Journal of Surgical Pathology, Vol. 13, No. 12, 1989, p. 1064-1067.

Research output: Contribution to journalArticle

Sakamoto, Michiie ; Hirohashi, S. ; Tsuda, H. ; Shimosato, Y. ; Makuuchi, M. ; Hosoda, Y. / Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern. In: American Journal of Surgical Pathology. 1989 ; Vol. 13, No. 12. pp. 1064-1067.
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