Multifocal renal cell carcinoma: Evidence for a common clonal origin

Hideaki Miyake, Hideo Nakamura, Isao Hara, Kazuo Gohji, Soichi Arakawa, Sadao Kamidono, Hideyuki Saya

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The reported incidence of satellite tumor lesions in kidneys resected by radical nephrectomy for renal cell carcinoma (RCC) is 7-25%; however, genetic analyses of satellite tumors in comparison with those of main tumor lesions have not been performed well. In the present study, we investigated the incidence of loss of heterozygosity (LOH) at chromosome arms 3p, 6q, 8p, 9p, 9q, and 14q using 18 microsatellite markers in 10 nonpapillary RCCs of 50 mm or less in diameter and the accompanying satellite tumor lesions to evaluate the genetic alterations in main and satellite tumors. LOH was detected in 10, 3, 5, 3, 2, and 3 cases at chromosome arms 3p, 6q, 8p, 9p, 9q, and 14q, respectively. In addition, primary and satellite tumor lesions in 8 of 10 cases exhibited identical patterns of LOH on the 18 loci examined. In the remaining two cases, both main and satellite tumors demonstrated LOH on the common seven and three loci, respectively, whereas for another locus, LOH was observed only in the satellite tumor lesions. The similarity of LOH patterns detected in main and satellite tumor lesions indicates that the presence of satellite tumors might be the result of intrarenal metastasis from the main tumor lesion. These findings strongly suggest that even in case of small nonpapillary RCC, nephron-sparing surgery might carry the risk of failing to prevent postoperative local recurrence due to the incomplete resection of unrecognized satellite tumors with genetic alterations similar to those of the main tumor.

Original languageEnglish
Pages (from-to)2491-2494
Number of pages4
JournalClinical Cancer Research
Volume4
Issue number10
Publication statusPublished - 1998 Oct
Externally publishedYes

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Renal Cell Carcinoma
Loss of Heterozygosity
Neoplasms
Chromosomes
Incidence
Nephrons
Nephrectomy
Microsatellite Repeats
Neoplasm Metastasis
Kidney
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Miyake, H., Nakamura, H., Hara, I., Gohji, K., Arakawa, S., Kamidono, S., & Saya, H. (1998). Multifocal renal cell carcinoma: Evidence for a common clonal origin. Clinical Cancer Research, 4(10), 2491-2494.

Multifocal renal cell carcinoma : Evidence for a common clonal origin. / Miyake, Hideaki; Nakamura, Hideo; Hara, Isao; Gohji, Kazuo; Arakawa, Soichi; Kamidono, Sadao; Saya, Hideyuki.

In: Clinical Cancer Research, Vol. 4, No. 10, 10.1998, p. 2491-2494.

Research output: Contribution to journalArticle

Miyake, H, Nakamura, H, Hara, I, Gohji, K, Arakawa, S, Kamidono, S & Saya, H 1998, 'Multifocal renal cell carcinoma: Evidence for a common clonal origin', Clinical Cancer Research, vol. 4, no. 10, pp. 2491-2494.
Miyake H, Nakamura H, Hara I, Gohji K, Arakawa S, Kamidono S et al. Multifocal renal cell carcinoma: Evidence for a common clonal origin. Clinical Cancer Research. 1998 Oct;4(10):2491-2494.
Miyake, Hideaki ; Nakamura, Hideo ; Hara, Isao ; Gohji, Kazuo ; Arakawa, Soichi ; Kamidono, Sadao ; Saya, Hideyuki. / Multifocal renal cell carcinoma : Evidence for a common clonal origin. In: Clinical Cancer Research. 1998 ; Vol. 4, No. 10. pp. 2491-2494.
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