Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera

Kazuomi Hanada, Jun Shimazaki, Shigeto Shimmura, Kazuo Tsubota

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

PURPOSE: To examine the efficacy of amniotic membrane transplantation in the treatment of deep corneal and scleral ulcers. PATIENTS: A total of 11 patients were recruited for this study: four patients (four eyes) with corneal perforation, five patients (five eyes) with a deep corneal ulcer and descemetocele, and two patients (two eyes) with a scleral ulcer. METHODS: Ulcers were treated by amniotic membrane transplantation. Separate amniotic membranes were transplanted as material to fill the stromal layer (amniotic membrane filling), as a basement membrane (amniotic membrane graft), and as a wound cover (amniotic membrane patch). After surgery, all cases were treated with artificial tears, autologous serum drops, antibiotic eyedrops, topical corticosteroids, and sodium hyaluronate eyedrops.RESULTS: Eight eyes (72.7%) healed with epithelialization in 16.5 ± 8.0 days (range, 7 to 29 days), with five and three eyes showing corneal epithelialization and conjunctival epithelialization, respectively. A persistent epithelial defect was noted in one eye with corneal ulcer after limbal allograft transplantation for a chemical burn and in two eyes with corneal ulcers as a complication of rheumatoid arthritis. CONCLUSION: Multilayered amniotic membrane transplantation may be effective for the treatment of deep ulceration of the cornea and sclera. In some eyes with total corneal limbal dysfunction or autoimmune disorders, amniotic membrane transplantation alone is not effective.

Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalAmerican Journal of Ophthalmology
Volume131
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Sclera
Amnion
Cornea
Transplantation
Corneal Ulcer
Ophthalmic Solutions
Ulcer
Corneal Perforation
Chemical Burns
Hyaluronic Acid
Basement Membrane
Allografts
Rheumatoid Arthritis
Adrenal Cortex Hormones
Anti-Bacterial Agents
Transplants
Wounds and Injuries
Therapeutics
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera. / Hanada, Kazuomi; Shimazaki, Jun; Shimmura, Shigeto; Tsubota, Kazuo.

In: American Journal of Ophthalmology, Vol. 131, No. 3, 2001, p. 324-331.

Research output: Contribution to journalArticle

@article{5064610e8a244045bbf66442de4f0c72,
title = "Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera",
abstract = "PURPOSE: To examine the efficacy of amniotic membrane transplantation in the treatment of deep corneal and scleral ulcers. PATIENTS: A total of 11 patients were recruited for this study: four patients (four eyes) with corneal perforation, five patients (five eyes) with a deep corneal ulcer and descemetocele, and two patients (two eyes) with a scleral ulcer. METHODS: Ulcers were treated by amniotic membrane transplantation. Separate amniotic membranes were transplanted as material to fill the stromal layer (amniotic membrane filling), as a basement membrane (amniotic membrane graft), and as a wound cover (amniotic membrane patch). After surgery, all cases were treated with artificial tears, autologous serum drops, antibiotic eyedrops, topical corticosteroids, and sodium hyaluronate eyedrops.RESULTS: Eight eyes (72.7{\%}) healed with epithelialization in 16.5 ± 8.0 days (range, 7 to 29 days), with five and three eyes showing corneal epithelialization and conjunctival epithelialization, respectively. A persistent epithelial defect was noted in one eye with corneal ulcer after limbal allograft transplantation for a chemical burn and in two eyes with corneal ulcers as a complication of rheumatoid arthritis. CONCLUSION: Multilayered amniotic membrane transplantation may be effective for the treatment of deep ulceration of the cornea and sclera. In some eyes with total corneal limbal dysfunction or autoimmune disorders, amniotic membrane transplantation alone is not effective.",
author = "Kazuomi Hanada and Jun Shimazaki and Shigeto Shimmura and Kazuo Tsubota",
year = "2001",
doi = "10.1016/S0002-9394(00)00825-4",
language = "English",
volume = "131",
pages = "324--331",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera

AU - Hanada, Kazuomi

AU - Shimazaki, Jun

AU - Shimmura, Shigeto

AU - Tsubota, Kazuo

PY - 2001

Y1 - 2001

N2 - PURPOSE: To examine the efficacy of amniotic membrane transplantation in the treatment of deep corneal and scleral ulcers. PATIENTS: A total of 11 patients were recruited for this study: four patients (four eyes) with corneal perforation, five patients (five eyes) with a deep corneal ulcer and descemetocele, and two patients (two eyes) with a scleral ulcer. METHODS: Ulcers were treated by amniotic membrane transplantation. Separate amniotic membranes were transplanted as material to fill the stromal layer (amniotic membrane filling), as a basement membrane (amniotic membrane graft), and as a wound cover (amniotic membrane patch). After surgery, all cases were treated with artificial tears, autologous serum drops, antibiotic eyedrops, topical corticosteroids, and sodium hyaluronate eyedrops.RESULTS: Eight eyes (72.7%) healed with epithelialization in 16.5 ± 8.0 days (range, 7 to 29 days), with five and three eyes showing corneal epithelialization and conjunctival epithelialization, respectively. A persistent epithelial defect was noted in one eye with corneal ulcer after limbal allograft transplantation for a chemical burn and in two eyes with corneal ulcers as a complication of rheumatoid arthritis. CONCLUSION: Multilayered amniotic membrane transplantation may be effective for the treatment of deep ulceration of the cornea and sclera. In some eyes with total corneal limbal dysfunction or autoimmune disorders, amniotic membrane transplantation alone is not effective.

AB - PURPOSE: To examine the efficacy of amniotic membrane transplantation in the treatment of deep corneal and scleral ulcers. PATIENTS: A total of 11 patients were recruited for this study: four patients (four eyes) with corneal perforation, five patients (five eyes) with a deep corneal ulcer and descemetocele, and two patients (two eyes) with a scleral ulcer. METHODS: Ulcers were treated by amniotic membrane transplantation. Separate amniotic membranes were transplanted as material to fill the stromal layer (amniotic membrane filling), as a basement membrane (amniotic membrane graft), and as a wound cover (amniotic membrane patch). After surgery, all cases were treated with artificial tears, autologous serum drops, antibiotic eyedrops, topical corticosteroids, and sodium hyaluronate eyedrops.RESULTS: Eight eyes (72.7%) healed with epithelialization in 16.5 ± 8.0 days (range, 7 to 29 days), with five and three eyes showing corneal epithelialization and conjunctival epithelialization, respectively. A persistent epithelial defect was noted in one eye with corneal ulcer after limbal allograft transplantation for a chemical burn and in two eyes with corneal ulcers as a complication of rheumatoid arthritis. CONCLUSION: Multilayered amniotic membrane transplantation may be effective for the treatment of deep ulceration of the cornea and sclera. In some eyes with total corneal limbal dysfunction or autoimmune disorders, amniotic membrane transplantation alone is not effective.

UR - http://www.scopus.com/inward/record.url?scp=0035126375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035126375&partnerID=8YFLogxK

U2 - 10.1016/S0002-9394(00)00825-4

DO - 10.1016/S0002-9394(00)00825-4

M3 - Article

C2 - 11239864

AN - SCOPUS:0035126375

VL - 131

SP - 324

EP - 331

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 3

ER -