Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 × 24 × 0.4 mm3 in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min-1 under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 νg min-1.

Original languageEnglish
Article number065031
JournalJournal of Micromechanics and Microengineering
Volume19
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Urea
Membranes
Polymeric membranes
Wet etching
Hydrostatic pressure
Uric Acid
Creatinine
Blood
Flow rate
Molecules
Acids
polyether sulfone

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering
  • Mechanics of Materials
  • Electronic, Optical and Magnetic Materials

Cite this

@article{fdee6c786c88409d92ea97501efe7080,
title = "Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney",
abstract = "We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 × 24 × 0.4 mm3 in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min-1 under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 νg min-1.",
author = "Ye Gu and Norihisa Miki",
year = "2009",
doi = "10.1088/0960-1317/19/6/065031",
language = "English",
volume = "19",
journal = "Journal of Micromechanics and Microengineering",
issn = "0960-1317",
publisher = "IOP Publishing Ltd.",
number = "6",

}

TY - JOUR

T1 - Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney

AU - Gu, Ye

AU - Miki, Norihisa

PY - 2009

Y1 - 2009

N2 - We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 × 24 × 0.4 mm3 in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min-1 under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 νg min-1.

AB - We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 × 24 × 0.4 mm3 in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min-1 under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 νg min-1.

UR - http://www.scopus.com/inward/record.url?scp=67849118864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67849118864&partnerID=8YFLogxK

U2 - 10.1088/0960-1317/19/6/065031

DO - 10.1088/0960-1317/19/6/065031

M3 - Article

AN - SCOPUS:67849118864

VL - 19

JO - Journal of Micromechanics and Microengineering

JF - Journal of Micromechanics and Microengineering

SN - 0960-1317

IS - 6

M1 - 065031

ER -