Abstract
To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
| Original language | English |
|---|---|
| Pages (from-to) | 201-205 |
| Number of pages | 5 |
| Journal | Molecular BioSystems |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Feb 1 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
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Cite this
Tan, B., Matsuda, A., Zhang, Y., Kuno, A., & Narimatsu, H. (2014). Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics. Molecular BioSystems, 10(2), 201-205. https://doi.org/10.1039/c3mb70430k