Abstract
To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
| Original language | English |
|---|---|
| Pages (from-to) | 201-205 |
| Number of pages | 5 |
| Journal | Molecular BioSystems |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Feb |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
Cite this
Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics. / Tan, Binbin; Matsuda, Atsushi; Zhang, Yan; Kuno, Atsushi; Narimatsu, Hisashi.
In: Molecular BioSystems, Vol. 10, No. 2, 02.2014, p. 201-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics
AU - Tan, Binbin
AU - Matsuda, Atsushi
AU - Zhang, Yan
AU - Kuno, Atsushi
AU - Narimatsu, Hisashi
PY - 2014/2
Y1 - 2014/2
N2 - To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
AB - To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
UR - http://www.scopus.com/inward/record.url?scp=84891384128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891384128&partnerID=8YFLogxK
U2 - 10.1039/c3mb70430k
DO - 10.1039/c3mb70430k
M3 - Article
VL - 10
SP - 201
EP - 205
JO - Molecular BioSystems
JF - Molecular BioSystems
SN - 1742-206X
IS - 2
ER -