Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics

Binbin Tan, Atsushi Matsuda, Yan Zhang, Atsushi Kuno, Hisashi Narimatsu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalMolecular BioSystems
Volume10
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

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ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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