Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics

Binbin Tan; Atsushi Matsuda; Yan Zhang; Atsushi Kuno; Hisashi Narimatsu

doi:10.1039/c3mb70430k

Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics

Binbin Tan, Atsushi Matsuda, Yan Zhang, Atsushi Kuno, Hisashi Narimatsu

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	Molecular BioSystems
Volume	10
Issue number	2
DOIs	https://doi.org/10.1039/c3mb70430k
Publication status	Published - 2014 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Molecular Biology

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abstract = "To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.",

author = "Binbin Tan and Atsushi Matsuda and Yan Zhang and Atsushi Kuno and Hisashi Narimatsu",

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AU - Tan, Binbin

AU - Matsuda, Atsushi

AU - Zhang, Yan

AU - Kuno, Atsushi

AU - Narimatsu, Hisashi

PY - 2014/2/1

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AB - To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.

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Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics

Abstract

ASJC Scopus subject areas

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