Abstract
To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
Original language | English |
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Pages (from-to) | 201-205 |
Number of pages | 5 |
Journal | Molecular BioSystems |
Volume | 10 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2014 Feb |
Externally published | Yes |
ASJC Scopus subject areas
- Biotechnology
- Molecular Biology