Multimodal Sensory Feedback Associated with Motor Attempts Alters BOLD Responses to Paralyzed Hand Movement in Chronic Stroke Patients

Takashi Ono, Yutaka Tomita, Manabu Inose, Tetsuo Ota, Akio Kimura, Meigen Liu, Junichi Ushiba

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Electroencephalogram-based brain–computer interfaces (BCI) have been used as a potential tool for training volitional regulation of corticomuscular drive in patients who have severe hemiplegia due to stroke. However, it is unclear whether ERD observed while attempting motor execution can be regarded as a neural marker that represents M1 excitability in survivors of severe stroke. Therefore we investigated the association between ERD and the blood-oxygen-level-dependent (BOLD) fMRI signal during attempted movement of a paralyzed finger in stroke patients. Nine chronic stroke patients received BCI training for finger extension movement 1 h daily for a duration of 1 month. The sensorimotor rhythm was recorded from the sensorimotor area of the damaged hemisphere, and ongoing amplitude variations were monitored using a BCI system. Either a visual alert or the action of a motor-driven orthosis was triggered in response to ERD of the sensorimotor rhythm while patients attempted extension movements of the paralyzed fingers. Inter-subject covariance between ERD and the BOLD response in the sensorimotor areas was calculated. After BCI training, an increased ERD over the damaged hemisphere was confirmed in all participants while they attempted extension of the affected finger and this increase was associated with a BOLD response in primary sensorimotor area. Whole-brain MRI revealed that the primary sensorimotor area and supplementary motor area were activated in the damaged hemisphere after 1 month of BCI training. ERD reflects the BOLD responses of the primary motor areas in either hemisphere while patients who have severe chronic hemiplegia due to a stroke attempt an extension movement of the paralyzed fingers. One month of BCI can alter motor-related brain area activation. Combining BCI with other methods to facilitate such changes may help to implement BCI for motor rehabilitation after stroke.

Original languageEnglish
Pages (from-to)340-351
Number of pages12
JournalBrain Topography
Volume28
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Sensory Feedback
Fingers
Hand
Stroke
Oxygen
Hemiplegia
Motor Cortex
Orthotic Devices
Brain
Survivors
Electroencephalography
Magnetic Resonance Imaging
Sensorimotor Cortex

Keywords

  • BOLD-fMRI
  • Event-related desynchronization
  • Hemiplegia
  • Motor related activity

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Multimodal Sensory Feedback Associated with Motor Attempts Alters BOLD Responses to Paralyzed Hand Movement in Chronic Stroke Patients. / Ono, Takashi; Tomita, Yutaka; Inose, Manabu; Ota, Tetsuo; Kimura, Akio; Liu, Meigen; Ushiba, Junichi.

In: Brain Topography, Vol. 28, No. 2, 2014, p. 340-351.

Research output: Contribution to journalArticle

@article{1aeef032999140e68687f85e155145ac,
title = "Multimodal Sensory Feedback Associated with Motor Attempts Alters BOLD Responses to Paralyzed Hand Movement in Chronic Stroke Patients",
abstract = "Electroencephalogram-based brain–computer interfaces (BCI) have been used as a potential tool for training volitional regulation of corticomuscular drive in patients who have severe hemiplegia due to stroke. However, it is unclear whether ERD observed while attempting motor execution can be regarded as a neural marker that represents M1 excitability in survivors of severe stroke. Therefore we investigated the association between ERD and the blood-oxygen-level-dependent (BOLD) fMRI signal during attempted movement of a paralyzed finger in stroke patients. Nine chronic stroke patients received BCI training for finger extension movement 1 h daily for a duration of 1 month. The sensorimotor rhythm was recorded from the sensorimotor area of the damaged hemisphere, and ongoing amplitude variations were monitored using a BCI system. Either a visual alert or the action of a motor-driven orthosis was triggered in response to ERD of the sensorimotor rhythm while patients attempted extension movements of the paralyzed fingers. Inter-subject covariance between ERD and the BOLD response in the sensorimotor areas was calculated. After BCI training, an increased ERD over the damaged hemisphere was confirmed in all participants while they attempted extension of the affected finger and this increase was associated with a BOLD response in primary sensorimotor area. Whole-brain MRI revealed that the primary sensorimotor area and supplementary motor area were activated in the damaged hemisphere after 1 month of BCI training. ERD reflects the BOLD responses of the primary motor areas in either hemisphere while patients who have severe chronic hemiplegia due to a stroke attempt an extension movement of the paralyzed fingers. One month of BCI can alter motor-related brain area activation. Combining BCI with other methods to facilitate such changes may help to implement BCI for motor rehabilitation after stroke.",
keywords = "BOLD-fMRI, Event-related desynchronization, Hemiplegia, Motor related activity",
author = "Takashi Ono and Yutaka Tomita and Manabu Inose and Tetsuo Ota and Akio Kimura and Meigen Liu and Junichi Ushiba",
year = "2014",
doi = "10.1007/s10548-014-0382-6",
language = "English",
volume = "28",
pages = "340--351",
journal = "Brain Topography",
issn = "0896-0267",
publisher = "Kluwer Academic/Human Sciences Press Inc.",
number = "2",

}

TY - JOUR

T1 - Multimodal Sensory Feedback Associated with Motor Attempts Alters BOLD Responses to Paralyzed Hand Movement in Chronic Stroke Patients

AU - Ono, Takashi

AU - Tomita, Yutaka

AU - Inose, Manabu

AU - Ota, Tetsuo

AU - Kimura, Akio

AU - Liu, Meigen

AU - Ushiba, Junichi

PY - 2014

Y1 - 2014

N2 - Electroencephalogram-based brain–computer interfaces (BCI) have been used as a potential tool for training volitional regulation of corticomuscular drive in patients who have severe hemiplegia due to stroke. However, it is unclear whether ERD observed while attempting motor execution can be regarded as a neural marker that represents M1 excitability in survivors of severe stroke. Therefore we investigated the association between ERD and the blood-oxygen-level-dependent (BOLD) fMRI signal during attempted movement of a paralyzed finger in stroke patients. Nine chronic stroke patients received BCI training for finger extension movement 1 h daily for a duration of 1 month. The sensorimotor rhythm was recorded from the sensorimotor area of the damaged hemisphere, and ongoing amplitude variations were monitored using a BCI system. Either a visual alert or the action of a motor-driven orthosis was triggered in response to ERD of the sensorimotor rhythm while patients attempted extension movements of the paralyzed fingers. Inter-subject covariance between ERD and the BOLD response in the sensorimotor areas was calculated. After BCI training, an increased ERD over the damaged hemisphere was confirmed in all participants while they attempted extension of the affected finger and this increase was associated with a BOLD response in primary sensorimotor area. Whole-brain MRI revealed that the primary sensorimotor area and supplementary motor area were activated in the damaged hemisphere after 1 month of BCI training. ERD reflects the BOLD responses of the primary motor areas in either hemisphere while patients who have severe chronic hemiplegia due to a stroke attempt an extension movement of the paralyzed fingers. One month of BCI can alter motor-related brain area activation. Combining BCI with other methods to facilitate such changes may help to implement BCI for motor rehabilitation after stroke.

AB - Electroencephalogram-based brain–computer interfaces (BCI) have been used as a potential tool for training volitional regulation of corticomuscular drive in patients who have severe hemiplegia due to stroke. However, it is unclear whether ERD observed while attempting motor execution can be regarded as a neural marker that represents M1 excitability in survivors of severe stroke. Therefore we investigated the association between ERD and the blood-oxygen-level-dependent (BOLD) fMRI signal during attempted movement of a paralyzed finger in stroke patients. Nine chronic stroke patients received BCI training for finger extension movement 1 h daily for a duration of 1 month. The sensorimotor rhythm was recorded from the sensorimotor area of the damaged hemisphere, and ongoing amplitude variations were monitored using a BCI system. Either a visual alert or the action of a motor-driven orthosis was triggered in response to ERD of the sensorimotor rhythm while patients attempted extension movements of the paralyzed fingers. Inter-subject covariance between ERD and the BOLD response in the sensorimotor areas was calculated. After BCI training, an increased ERD over the damaged hemisphere was confirmed in all participants while they attempted extension of the affected finger and this increase was associated with a BOLD response in primary sensorimotor area. Whole-brain MRI revealed that the primary sensorimotor area and supplementary motor area were activated in the damaged hemisphere after 1 month of BCI training. ERD reflects the BOLD responses of the primary motor areas in either hemisphere while patients who have severe chronic hemiplegia due to a stroke attempt an extension movement of the paralyzed fingers. One month of BCI can alter motor-related brain area activation. Combining BCI with other methods to facilitate such changes may help to implement BCI for motor rehabilitation after stroke.

KW - BOLD-fMRI

KW - Event-related desynchronization

KW - Hemiplegia

KW - Motor related activity

UR - http://www.scopus.com/inward/record.url?scp=84939884817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939884817&partnerID=8YFLogxK

U2 - 10.1007/s10548-014-0382-6

DO - 10.1007/s10548-014-0382-6

M3 - Article

VL - 28

SP - 340

EP - 351

JO - Brain Topography

JF - Brain Topography

SN - 0896-0267

IS - 2

ER -