Multiple endocrine neoplasia

Hiroshi Takami, Yoshifumi Ikeda, Kaori Kameyama

Research output: Contribution to journalArticle

Abstract

In multiple endocrine neoplasia (MEN) syndromes, tumors appear either synchronously or heterochronously in a combination of 2 or more specified endocrine glands. They are broadly classified as MEN 1 or MEN 2 according to the combination of tumors, and are inherited as an autosomal dominant trait. The genes responsible for these syndromes have been identified, making early diagnosis based on familial screening possible. The gene responsible for MEN 1 is located on the long arm of chromosome 11. It is a tumor suppressor gene that codes for menin. The cause of MEN 2 type is a mutation of the RET proto-oncogene on the long arm of chromosome 10. The present article discusses the diagnosis and treatment of these syndromes.

Original languageEnglish
Pages (from-to)508-511
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume29
Issue number4
Publication statusPublished - 2002 Apr
Externally publishedYes

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Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Type 2a
Endocrine Glands
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Proto-Oncogenes
Tumor Suppressor Genes
Genes
Early Diagnosis
Neoplasms
Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Multiple endocrine neoplasia. / Takami, Hiroshi; Ikeda, Yoshifumi; Kameyama, Kaori.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 29, No. 4, 04.2002, p. 508-511.

Research output: Contribution to journalArticle

Takami, H, Ikeda, Y & Kameyama, K 2002, 'Multiple endocrine neoplasia', Japanese Journal of Cancer and Chemotherapy, vol. 29, no. 4, pp. 508-511.
Takami, Hiroshi ; Ikeda, Yoshifumi ; Kameyama, Kaori. / Multiple endocrine neoplasia. In: Japanese Journal of Cancer and Chemotherapy. 2002 ; Vol. 29, No. 4. pp. 508-511.
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