Multiple endocrine neoplasia 1 (MEN 1)

Kaori Kameyama, H. Takami

Research output: Contribution to journalArticle

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and anterior pituitary. In 1997, the MEN 1 gene was identified and cloned. It is on chromosome 11q13 and has 10 exons. It encodes a 610 amino acid protein called MENIN. However, many different germline mutations in MEN 1 families have reported, there were no hotspot of mutation. The correlation between MEN 1 mutation and clinical datas has not been established yet. Recently, the possible function of MENIN protein has reported. The identification of MEN 1 mutation by employing DNA test, will facilitate early diagnosis and treatment.

Original languageEnglish
Pages (from-to)1434-1436
Number of pages3
JournalNippon rinsho. Japanese journal of clinical medicine
Volume58
Issue number7
Publication statusPublished - 2000

Fingerprint

Multiple Endocrine Neoplasia
Mutation
Multiple Endocrine Neoplasia Type 1
Germ-Line Mutation
Early Diagnosis
Exons
Neoplasms
Proteins
Chromosomes
Amino Acids
DNA
Genes

Cite this

Multiple endocrine neoplasia 1 (MEN 1). / Kameyama, Kaori; Takami, H.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 58, No. 7, 2000, p. 1434-1436.

Research output: Contribution to journalArticle

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