Multiple myeloma relapse in the irradiated liver: Involvement of hepatocyte growth factor akin to that after hepatocyte transplantation

Akiko Uetake, Atsuya Takeda, Naoyuki Shigematsu, Eiji Ikeda, Minako Kametaka, Toshio Ohashi, Etsuo Kunieda

Research output: Contribution to journalArticlepeer-review

Abstract

We described a rare case of multiple myeloma in a 60-year-old man, in whom relapse limited to the irradiated area in the left lobe of the liver developed following radiotherapy for lesions in 11th and 12th thoracic spines. Immunohistochemical analysis revealed expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (c-Met) in the hepatocytes in the irradiated area of the liver. We speculate that the malignant plasma cells might have proliferated in response to local increase of HGF production in the irradiated liver. The role of HGF in the extraosseous spread of multiple myeloma and also under the experimental condition of hepatic transplantation is discussed.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalJournal of Radiotherapy in Practice
Volume11
Issue number4
DOIs
Publication statusPublished - 2012 Dec

Keywords

  • hepatic growth factor
  • hepatocyte transplantation
  • myeloma
  • radiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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