Multiple myeloma relapse in the irradiated liver: Involvement of hepatocyte growth factor akin to that after hepatocyte transplantation

Akiko Uetake; Atsuya Takeda; Naoyuki Shigematsu; Eiji Ikeda; Minako Kametaka; Toshio Ohashi; Etsuo Kunieda

doi:10.1017/S1460396912000131

Multiple myeloma relapse in the irradiated liver: Involvement of hepatocyte growth factor akin to that after hepatocyte transplantation

Akiko Uetake, Atsuya Takeda, Naoyuki Shigematsu, Eiji Ikeda, Minako Kametaka, Toshio Ohashi, Etsuo Kunieda

Department of Radiology (Radiation Oncology)

Research output: Contribution to journal › Article › peer-review

Abstract

We described a rare case of multiple myeloma in a 60-year-old man, in whom relapse limited to the irradiated area in the left lobe of the liver developed following radiotherapy for lesions in 11th and 12th thoracic spines. Immunohistochemical analysis revealed expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (c-Met) in the hepatocytes in the irradiated area of the liver. We speculate that the malignant plasma cells might have proliferated in response to local increase of HGF production in the irradiated liver. The role of HGF in the extraosseous spread of multiple myeloma and also under the experimental condition of hepatic transplantation is discussed.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	Journal of Radiotherapy in Practice
Volume	11
Issue number	4
DOIs	https://doi.org/10.1017/S1460396912000131
Publication status	Published - 2012 Dec

Keywords

hepatic growth factor
hepatocyte transplantation
myeloma
radiation

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Oncology

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10.1017/S1460396912000131

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abstract = "We described a rare case of multiple myeloma in a 60-year-old man, in whom relapse limited to the irradiated area in the left lobe of the liver developed following radiotherapy for lesions in 11th and 12th thoracic spines. Immunohistochemical analysis revealed expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (c-Met) in the hepatocytes in the irradiated area of the liver. We speculate that the malignant plasma cells might have proliferated in response to local increase of HGF production in the irradiated liver. The role of HGF in the extraosseous spread of multiple myeloma and also under the experimental condition of hepatic transplantation is discussed.",

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T2 - Involvement of hepatocyte growth factor akin to that after hepatocyte transplantation

AU - Uetake, Akiko

AU - Takeda, Atsuya

AU - Shigematsu, Naoyuki

AU - Ikeda, Eiji

AU - Kametaka, Minako

AU - Ohashi, Toshio

AU - Kunieda, Etsuo

PY - 2012/12

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N2 - We described a rare case of multiple myeloma in a 60-year-old man, in whom relapse limited to the irradiated area in the left lobe of the liver developed following radiotherapy for lesions in 11th and 12th thoracic spines. Immunohistochemical analysis revealed expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (c-Met) in the hepatocytes in the irradiated area of the liver. We speculate that the malignant plasma cells might have proliferated in response to local increase of HGF production in the irradiated liver. The role of HGF in the extraosseous spread of multiple myeloma and also under the experimental condition of hepatic transplantation is discussed.

AB - We described a rare case of multiple myeloma in a 60-year-old man, in whom relapse limited to the irradiated area in the left lobe of the liver developed following radiotherapy for lesions in 11th and 12th thoracic spines. Immunohistochemical analysis revealed expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (c-Met) in the hepatocytes in the irradiated area of the liver. We speculate that the malignant plasma cells might have proliferated in response to local increase of HGF production in the irradiated liver. The role of HGF in the extraosseous spread of multiple myeloma and also under the experimental condition of hepatic transplantation is discussed.

KW - hepatic growth factor

KW - hepatocyte transplantation

KW - myeloma

KW - radiation

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Multiple myeloma relapse in the irradiated liver: Involvement of hepatocyte growth factor akin to that after hepatocyte transplantation

Abstract

Keywords

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